Sitagil M 100 mg+1000 mg (Tablet (Extended Release))

Unit Price: ৳ 35.00 (3 x 6: ৳ 630.00)
Strip Price: ৳ 210.00

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Incepta pharmaceuticals ltd
Also available as
Sitagil m 50 mg tablet Sitagil m 50 mg tablet

Indications

  • Adjunct to diet and exercise for glycemic control in type 2 diabetes mellitus
  • Not indicated for type 1 diabetes or diabetic ketoacidosis
  • Not studied in patients with a history of pancreatitis
  • Recommended limitations of use

Pharmacology

  • Combines sitagliptin and metformin for glycemic control in type 2 diabetes
  • Mechanisms of action of sitagliptin and metformin
  • Incretin hormone regulation
  • Glucose homeostasis regulation
  • DPP-4 inhibitor

Dosage & Administration

  • Individualized dosage based on patient's regimen
  • Maximum recommended daily dose
  • Twice-daily administration with meals
  • Gradual dose escalation for reduced gastrointestinal side effects
  • Recommended starting dose for patients not currently treated with metformin
  • Starting dose in patients already treated with metformin
  • Extended-release tablet dosage

Interaction

  • Cationic drugs and renal tubular secretion
  • Effect on phenprocoumon anticoagulant effect
  • Levothyroxine interaction
  • Interaction with insulin secretagogue or insulin

Contraindications

  • Contraindicated in renal disease or dysfunction
  • Acute or chronic metabolic acidosis
  • History of serious hypersensitivity reaction
  • Temporary discontinuation for radiologic studies involving contrast materials

Side Effects

  • Common adverse reactions
  • Adverse reactions in combination therapy
  • Hypoglycemia
  • Adverse reactions due to initiation of metformin therapy

Pregnancy & Lactation

  • Pregnancy Category B
  • Safety in pregnant women is not known
  • Caution during nursing

Precautions & Warnings

  • Risk of lactic acidosis
  • Symptoms and laboratory abnormalities
  • Long-term treatment associated with decrease in vitamin B12
  • Hepatic disease precaution
  • Assessment of renal function
  • Monitoring for pancreatic complications
  • Monitoring of hematologic parameters
  • Caution against excessive alcohol intake
  • Need for temporary insulin use during periods of stress
  • Evaluation for evidence of ketoacidosis or lactic acidosis
  • Macrovascular risk reduction
  • Allergic and hypersensitivity reactions

Overdose Effects

  • Supportive measures for sitagliptin overdose
  • Dialyzable nature of sitagliptin
  • Overdose of metformin hydrochloride
  • Dialyzable clearance of metformin
  • Pancreatitis in metformin overdose context

Therapeutic Class

  • Combination oral hypoglycemic preparations

Storage Conditions

  • Temperature and light storage conditions
  • Safety and expiry precautions

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