Liglimet 2.5 mg+500 mg (Tablet)
Unit Price: ৳ 12.00 (5 x 6: ৳ 360.00)
Strip Price: ৳ 72.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Adjunct to diet and exercise for glycemic control in adults with type 2 diabetes mellitus
Pharmacology
- Increases active incretin hormones
- Stimulates insulin release from pancreatic beta cells
- Decreases glucagon secretion from pancreatic alpha cells
- Lowers basal and postprandial plasma glucose
- Improves insulin sensitivity
Dosage & Administration
- Maximum recommended dose 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
- Recommended starting dose for patients not treated with Metformin Hydrochloride
- Dose escalation for reduced gastrointestinal side effects
- Different doses for immediate and extended release tablets
Interaction
- Potential interaction with cationic drugs
- Risk of metabolic acidosis with carbonic anhydrase inhibitors
- Decreased Linagliptin exposure with inducers of P-glycoprotein and CYP3A4 enzymes
- Drugs affecting glycemic control
Contraindications
- Contraindicated in renal impairment
- Contraindicated in acute or chronic metabolic acidosis
- Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Most common side effects are nasopharyngitis and diarrhea
- Increased risk of hypoglycemia
Pregnancy & Lactation
- Use during pregnancy only if clearly needed
- Caution during lactation
Precautions & Warnings
- Discontinue in case of lactic acidosis or suspected pancreatitis
- Monitoring of Vitamin B12 levels
- Importance of alcohol and other medicines
- Travel considerations
- Emergency preparedness
- Symptoms and treatment of hypoglycemia
Overdose Effects
- Usual supportive measures in case of overdose
- Unlikely removal of Linagliptin by dialysis
- Dialyzable Metformin Hydrochloride
- No dose-related adverse drug reactions
Therapeutic Class
- Combination oral hypoglycemic preparations
Storage Conditions
- Keep in a cool & dry place below 30°C
- Protected from light & moisture
- Keep out of the reach of children