Acecard 1.25 mg (Tablet)

Indications

• Lowering blood pressure
• Treating hypertension
• Managing congestive heart failure
• Post-myocardial infarction treatment
• Treating glomerular or incipient nephropathy
• Reducing the risk of myocardial infarction
• Reducing the risk of stroke
• Reducing the risk of cardiovascular death
• Prevention of major cardiovascular events

Pharmacology

• ACE inhibitor
• Blocks conversion of angiotensin I to angiotensin II
• Decreases vasopressor activity
• Decreases aldosterone secretion
• Long-acting
• Well-tolerated
• Effective in heart failure management

Dosage

• Initial dose of 1.25-2.5 mg once daily for hypertension
• Maintenance dosage of 2.5-20 mg daily
• Initial dose of 2.5 mg twice daily for heart failure after myocardial infarction
• Titration to a target daily dose of 5 mg twice daily

Administration

• Swallow tablets with sufficient liquid
• Do not chew or crush tablets
• Can be taken before, during, or after a meal

Interactions

• Concomitant administration with diuretics
• Concomitant therapy with lithium
• Alcohol may exacerbate effects on driving ability
• NSAIDs may reduce antihypertensive effect

Contraindications

• Hypersensitivity to ramipril or any other ACE inhibitor
• History of angioedema
• Concomitant sacubitril/valsartan therapy
• Relevant renal artery stenosis
• Hypotensive or haemodynamically unstable states
• Concomitant aliskiren-containing medicines
• Concomitant angiotensin II receptor antagonists
• During pregnancy

Side Effects

• Dizziness
• Headache
• Fatigue
• Asthenia
• Symptomatic hypotension
• Cough
• Nausea
• Vomiting
• Diarrhea
• Rash
• Urticaria
• Oliguria
• Anxiety
• Amnesia
• Angioneurotic edema
• Anaphylactic reactions
• Hyperkalemia

Pregnancy & Lactation

• Must be avoided during pregnancy
• Pregnancy must be excluded before starting treatment
• Not recommended during breastfeeding

Precautions & Warnings

• Use with caution in patients with impaired renal function
• Use with caution in patients with hyperkalemia
• Use with caution in patients with hypotension
• Use with caution in patients with impaired hepatic function

Use in Special Populations

• Elderly patients: consider a reduced initial dose
• Hepatic impairment: initiate treatment under close medical supervision
• Renal impairment: consider a reduced initial dose
• Consideration for patients pretreated with a diuretic

Overdose Effects

• Excessive peripheral vasodilatation
• Marked hypotension
• Shock
• Bradycardia
• Electrolyte disturbances
• Renal failure

Therapeutic Class

• Angiotensin-converting enzyme (ACE) inhibitors

Storage Conditions

• Store at 30°C or below
• Protect from light
• Do not use after the expiry date
• Dispensed only on a registered physician's prescription

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