Methigic 16 mg (Tablet)

Unit Price: ৳ 20.50 (2 x 10: ৳ 410.00)
Strip Price: ৳ 205.00

Medicine Details

Category Details
Generic Methylprednisolone
Company Square pharmaceuticals plc
Also available as
Methigic 2 mg tablet Methigic 4 mg tablet Methigic 8 mg tablet

Title

Methigic Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

Potent anti-inflammatory steroid with greater potency than Prednisolone and less tendency to induce sodium and water retention. Used to treat various diseases such as endocrine disorders, rheumatic disorders, collagen diseases, dermatologic diseases, allergy, ophthalmic diseases, respiratory diseases, neoplastic diseases, edematous states, gastrointestinal disease, CNS disease, hematological disorders, and more.

Color Options

  • White

Functions

  • Anti-inflammatory
  • Immunosuppressive
  • Anti-allergic
  • Diuretic

Materials

  • Methylprednisolone

Technical Specifications

  • Relative potency to Hydrocortisone is at least four to one
  • Absolute bioavailability of 82% to 89% following oral administration
  • Plasma protein binding of approximately 77%
  • Metabolized in the liver to inactive metabolites

Design Elements

  • Tablet form

Usability Features

  • Usual dosage range of 2-48 mg daily in divided doses
  • Alternate-day therapy regimen for long-term use

Dimensions

Available in 4 mg tablet form

Indications

  • Primary or Secondary Adrenocortical Insufficiency
  • Congenital Adrenal Hyperplasia
  • Rheumatoid Arthritis
  • Systemic Lupus Erythematosus
  • Nephrotic Syndrome

Pharmacology

  • Pharmacodynamic Properties: Potent anti-inflammatory agent with the capacity to profoundly inhibit the immune system
  • Pharmacokinetic Properties: Rapidly absorbed, widely distributed into tissues, crosses the blood-brain barrier, metabolized in the liver, haemodializable

Dosage & Administration

  • Usual Dosage Range: 2-48 mg daily in divided doses
  • Maintenance Dosage: Determined by decreasing the initial drug dosage in small decrements
  • Multiple Sclerosis Treatment: Daily doses of 160 mg for a week followed by 64 mg every other day

Interactions

  • Inhibitors:
    • Erythromycin
    • Clarithromycin
    • Phenobarbital
    • Phenytoin
    • Rifampin
    • Ketoconazole
  • Enhancers:
    • Estrogens

Contraindications

  • Systemic fungal infections
  • Known hypersensitivity to components

Side Effects

  • Fluid retention
  • Weight gain
  • High blood pressure
  • Glaucoma
  • Cataracts
  • Growth retardation in children

Pregnancy & Lactation

Pregnancy Category C, should be given only if potential benefit justifies potential risk to the fetus

Precautions & Warnings

  • Adrenocortical insufficiency may persist for months after discontinuation of therapy
  • Enhanced effect on patients with hypothyroidism and in those with cirrhosis
  • Corticosteroids should be used cautiously in patients with ocular herpes simplex

Overdose Effects

No specific antidote available; treatment is supportive and symptomatic

Therapeutic Class

Glucocorticoids

Storage Conditions

Store in a cool and dry place, away from light

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