Arixon 2 gm/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic with potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms, interferes with the synthesis of the bacterial cell wall, has high stability in the presence of beta lactamases, and a relatively long plasma elimination half-life of about 6 to 9 hours.
Dosage
- Adult:
- 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 4 gm/day
- Infants and Children (01 month or older):
- 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Maximum dose: 2 gm/day
Administration
- Preparation of Solutions for Intramuscular / Intravenous Injections
- The injection should be administered over 2-4 minutes, by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL
- Freshly reconstituted solution
Interaction
No drug interactions reported
Contraindications
Should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics
Side Effects
- gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
- cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
- hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
- hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
- CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
- Local phlebitis following intravenous administration
Pregnancy & Lactation
Safety in human pregnancy not established, caution with lactating mothers
Precautions & Warnings
- Anaphylactic shock precautions
- Gallbladder sludge findings
- Blood picture check during prolonged treatment
Use in Special Populations
Not to be given to neonates if premature and newborn (up to 28 days of age)
Overdose Effects
No specific antidote, symptomatic treatment for overdosage
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Store in cool, dry place (below 30° C), away from light & moisture, keep out of the reach of children