Opton 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 10.00 (6 x 10: ৳ 600.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company Beximco pharmaceuticals ltd
Also available as
Opton 20 mg tablet Opton 40 mg tablet Opton 20 mg capsule

Title and Description

  • Opton 40 mg Capsule
  • Proton pump inhibitor for heartburn relief and GERD symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Zollinger-Ellison Syndrome relief
  • Acid-related Dyspepsia treatment
  • Duodenal & Gastric ulcer relief

Indications

  • Relief from chronic heartburn symptoms
  • Relief from symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Treatment of Acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Peak plasma levels at approximately 1.5 hours after oral administration
  • Extensive metabolism in the liver by cytochrome P450 enzyme system
  • Low percentage of excretion in the urine
  • Absorption, Distribution, Metabolism, Excretion (ADME) profile

Dosage

  • 20 mg or 40 mg Once Daily for Healing of Erosive Esophagitis
  • 20 mg Once Daily for Maintenance of Healing of Erosive Esophagitis
  • 20 mg Once Daily for Symptomatic GERD
  • Triple Therapy for Helicobacter Pylori eradication
  • Dosing for Zollinger-Ellison Syndrome
  • 20-40 mg Once Daily for Acid-related Dyspepsia
  • 20 mg Once Daily for Duodenal ulcer
  • 20-40 mg Once Daily for Gastric ulcer
  • Dosage for IV Injection or IV infusion in adult and pediatric patients
  • Dosing for risk reduction of rebleeding of Gastric or Duodenal Ulcers following therapeutic endoscopy in adults

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Instructions for Oral Suspension preparation and administration
  • IV Injection administration protocol and preparation
  • Storage and preparation of IV infusion solution

Interactions

  • Metabolism by CYP2C19 and CYP3A4
  • Inhibition of drug absorption due to gastric pH alteration
  • No clinically significant interactions with specific drugs
  • Potential interference with CYP2C19 metabolism
  • Increased plasma levels in certain drug combinations

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Common adverse events include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth
  • No difference in types of related adverse events seen during maintenance treatment compared to short term treatment

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies revealing no teratogenic effects
  • Excretion in milk not studied
  • Discontinuation of breastfeeding if essential use is considered

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Instructions for patients with difficulty swallowing capsules
  • Allowable use of antacids while taking Opton

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No significant differences in safety and efficacy in geriatric patients
  • No dosage adjustment required for patients with mild to moderate hepatic insufficiency
  • Expected unchanged pharmacokinetics in renal impairment patients

Overdose Effects

  • Signs of acute toxicity in animal studies
  • No specific antidote known
  • Symptomatic and supportive treatment recommended
  • Consideration of multiple drug ingestion in overdose management

Storage Conditions

  • Storage at a temperature not exceeding 30°C in a dry place
  • Protection from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image

Commonly Asked Questions

  • What is Opton 40 mg Capsule and its uses?
  • Side effects of Opton 40 mg Capsule
  • Pregnancy and breastfeeding considerations
  • Time for Opton 40 mg Capsule to start working
  • Quick Tips for Opton 40 mg Capsule users

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