Avloclav 250 mg+125 mg (Tablet)

Indications

• Short-term treatment of bacterial infections
• Upper respiratory tract infections
• Lower respiratory tract infections
• Genito-urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections
• Other infections

Composition

• 375 mg tablet: Amoxicillin 250 mg + Clavulanic Acid 125 mg
• 625 mg tablet: Amoxicillin 500 mg + Clavulanic Acid 125 mg
• 1 gm tablet: Amoxicillin 875 mg + Clavulanic Acid 125 mg
• Powder for Suspension: Amoxicillin 125 mg + Clavulanic Acid 31.25 mg
• Powder for Suspension (Forte): Amoxicillin 400 mg + Clavulanic Acid 57.5 mg
• 1.2 gm Injection: Amoxicillin Sodium 1 gm + Clavulanate Potassium 200 mg
• 0.6 gm injection: Amoxicillin Sodium 500 mg + Clavulanate Potassium 100 mg

Pharmacology

• Antibacterial combination of Amoxicillin and Clavulanic Acid
• Broad spectrum of bactericidal activity
• Inactivation of beta-lactamase enzymes
• Optimized absorption at the start of a meal
• Closely matched pharmacokinetics of the two components

Dosage

• Different dosages for adults and children
• Various dosage forms: tablet, suspension, forte suspension, IV injection
• Adjusted dosage for more severe infections
• Oral form can be taken without regard to meals, but enhanced absorption at the start of a meal

Administration

• Oral dosage form can be taken without regard to meals
• IV injection not suitable for intramuscular or subcutaneous administration
• Reconstituted vial to be used within 20 minutes, any unused material should be discarded

Interaction

• Prolongation of bleeding time and prothrombin time reported
• Possible reduction of efficacy of oral contraceptives
• Concomitant use of allopurinol can increase allergic skin reactions
• No data on concomitant use of Co-amoxiclav and allopurinol

Contraindications

• History of Penicillin hypersensitivity
• Possible cross-sensitivity with other beta-lactam antibiotics
• Contraindicated for patients with previous Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

• Uncommon and mild side effects
• Gastrointestinal side effects can be reduced by taking with meals
• Rare cases of hepatitis, cholestatic jaundice, and skin reactions reported
• Rare cases of angioedema and anaphylaxis reported

Pregnancy & Lactation

• Animal studies show no teratogenic effect
• Limited use in human pregnancy with no untoward effects reported
• Not recommended in pregnancy unless considered essential
• Trace quantities detected in breast milk during lactation

Precautions & Warnings

• Careful use in patients on anticoagulation therapy or with severe hepatic dysfunction
• Dosage adjustment for patients with moderate or severe renal impairment
• Adequate fluid intake and urinary output maintenance during high dose administration

Use in Special Populations

• Dose adjustment for patients with renal impairment and hepatic impairment
• Reduced dosage for children with renal or hepatic impairment

Overdose Effects

• Unlikely occurrence of overdose problems
• Possible gastrointestinal symptoms and electrolyte imbalances
• Potential removal from circulation by haemodialysis

Therapeutic Class

• Broad spectrum penicillins

Reconstitution

• IV injection reconstitution with Water for Injection BP
• Not suitable for mixing with certain solutions
• Reconstituted solution can be injected into infusion fluids over a specified period

Storage Conditions

• Store below 25°C, protected from light and moisture
• Reconstituted suspension to be kept in the refrigerator and used within 7 days
• Reconstituted vial must be used within 20 minutes

Related Brands

• Avloclav 500 mg+125 mg (Tablet) - aci-limited
• Avloclav 875 mg+125 mg (Tablet) - aci-limited
• Avloclav (125 mg+31.25 mg)/5 ml (Powder for Suspension) - aci-limited
• Avloclav (500 mg+100 mg)/10 ml (IV Injection) - aci-limited
• Avloclav (1 gm+200 mg)/20 ml (IV Injection) - aci-limited