Avloclav 500 mg+125 mg (Tablet)
Unit Price: ৳ 35.00 (3 x 6: ৳ 630.00)
Strip Price: ৳ 210.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Amoxicillin clavulanic acid |
| Company | Aci limited |
| Also available as |
Indications
- Short-term treatment of bacterial infections
- Upper respiratory tract infections
- Lower respiratory tract infections
- Genito-urinary tract infections
- Skin and soft tissue infections
- Bone and joint infections
- Other infections
Composition
- 375 mg tablet
- 625 mg tablet
- 1 gm tablet
- Powder for Suspension
- Powder for Suspension (Forte)
- 1.2 gm Injection
- 0.6 gm injection
Pharmacology
- Broad spectrum of bactericidal activity
- Susceptible to degradation by (3-lactamases
- Inactivation of beta-lactamase enzymes
- Optimized absorption at the start of a meal
- Low levels of serum binding
Dosage
- Usual adult dose: 625 mg Tablet every 12 hours
- For more severe infections: 1 gm Tablet every 12 hours
- Children dosage based on age and weight
- IV injection dosage for adults and children
Administration
- Oral dosage form can be taken without regard to meals
- Enhanced absorption when taken at the start of a meal
- IV injection suitable for intravenous administration
Interaction
- Prolongation of bleeding time and prothrombin time reported
- Reduced efficacy of oral contraceptives
- Potential interaction with allopurinol
Contraindications
- History of Penicillin hypersensitivity
- Cross-sensitivity with other beta-lactam antibiotics
Side Effects
- Uncommon and mainly of a mild and transitory nature
- Gastrointestinal side effects may be reduced by taking with meals
- Rare cases of hepatitis, cholestatic jaundice, and skin reactions reported
Pregnancy & Lactation
- Animal studies show no teratogenic effect
- Limited human use in pregnancy with no untoward effect
- Trace quantities detected in breast milk
Precautions & Warnings
- Use with care in patients on anticoagulation therapy
- Dosage adjustment for patients with hepatic or renal impairment
- Maintain adequate fluid intake and urinary output during high dose administration
Use in Special Populations
- Dosage adjustment for patients with renal impairment
- Use with caution in patients with hepatic impairment
Overdose Effects
- Unlikely to occur
- Gastrointestinal symptoms and fluid imbalance may be evident
- Can be removed by haemodialysis
Therapeutic Class
- Broad spectrum penicillins
Reconstitution
- IV injection reconstitution with Water for Injection BP
- Not to be mixed with certain solutions or fluids
- Can be injected into infusion fluids over a period of 3-4 minutes
Storage Conditions
- Store below 25°C, protected from light and moisture
- Reconstituted suspension should be kept in the refrigerator and used within 7 days
- Reconstituted vial must be used within 20 minutes