Avlosef 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 120.00

Medicine Details

Category	Details
Generic	Cephradine
Company	Aci limited
Also available as	Avlosef 250 mg capsule Avlosef 500 mg capsule Avlosef 125 mg pediatric drop Avlosef ds 250 mg suspension Avlosef 1 gm injection

Indications

Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
Treatment of upper respiratory tract infections
Treatment of lower respiratory tract infections
Treatment of urinary tract infections
Treatment of skin and soft tissue infections

Pharmacology

Cephradine is a semisynthetic broad spectrum bactericidal antibiotic
Active against both gram-positive and gram-negative microorganisms
Inhibits cross-linking process in the cell wall of bacteria
Bactericidal action due to lysis of bacteria from external osmotic pressure

Dosage & Administration

Oral administration for adults
Oral administration for children
Oral administration for elderly
Injectable administration for adults
Injectable administration for children

Interaction

Increased risk of kidney damage with concomitant use of nephrotoxic drugs
Enhanced possibility of renal toxicity with diuretics and probenecid

Contraindications

Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

Gastro-intestinal disturbances
Hypersensitivity phenomena
Skin reactions
Glossitis
Heartburn
Dizziness
Nausea
Vomiting
Diarrhoea
Abdominal pain
Vaginitis
Candida overgrowth
Blood disorders
Fever
Serum sickness like reactions
Anaphylaxis
Confusion
Liver enzyme disturbances
Transient hepatitis
Reversible interstitial nephritis

Pregnancy & Lactation

No demonstrated teratogenicity in animal studies
Excretion in breast milk
Caution in lactating mothers

Precautions & Warnings

Prolonged use may result in development of superinfection
Careful administration to patients hypersensitive to penicillins
Potential positive result in Coombs' testing
Potential false positive urine glucose result
Dosage adjustment in renal impairment
Contains lactose, caution in patients with specific hereditary problems

Use in Special Populations

Recommended doses for patients with renal impairment not on haemodialysis
Recommended doses for patients on chronic, intermittent haemodialysis
Higher doses may be required for chronic or severe infections
Monitoring required throughout treatment of chronic urinary tract infections

Overdose Effects

Non-specific symptoms include nausea, vomiting, and diarrhoea
Mainly supportive treatment
Gastric lavage necessary for large ingestions

Therapeutic Class

First generation Cephalosporins

Storage Conditions

Freshly prepare Avlosef Suspension
Use reconstituted Suspension within specified timeframes
Use Injection solutions within specified timeframes
Variations in color of reconstituted solutions do not affect potency
Do not use later than the date of expiry
Keep out of the reach of children

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