Doximar 100 mg/5 ml (Syrup)

100 ml bottle: ৳ 110.00

Medicine Details

Category Details
Generic Doxophylline
Company Aci limited
Also available as
Doximar 400 mg tablet Doximar 200 mg tablet

Title

  • Doximar - Doxophylline Tablet/Syrup

Categories

  • Medicine
  • Pharmaceutical

Description

  • Used to treat bronchial asthma, bronchospasm, chronic obstructive pulmonary disease (COPD), pulmonary disease with spastic bronchial component
  • Novel bronchodilator with decreased affinities toward adenosine A1 and A2 receptors
  • Selectively inhibits phosphodiesterase 4 to relax bronchial smooth muscle
  • Dosage for elderly: 200 mg tablet two or three times daily
  • Dosage for adults: 400 mg tablet two or three times daily
  • Dosage for children: varies based on age and body weight
  • Should not be administered with other xanthine preparations
  • Interaction caution with ephedrine or other sympathomimetic drugs
  • Contraindicated in individuals with known hypersensitivity to the drug or other xanthine derivatives, acute myocardial infarction, hypotension, and during lactation
  • Side effects may include nausea, vomiting, epigastric pain, headache, irritability, insomnia, tachycardia, extrasystoles, tachypnea, hyperglycemia, albuminuria, severe cardiac arrhythmias, and tonic-clonic seizure
  • Caution advised during pregnancy and lactation
  • Does not affect the ability to drive or use machines
  • Precautions for administering to patients with various conditions such as cardiac disease, hypertension, hypoxemia, hyperthyroidism, chronic corpulmonale, congestive heart failure, liver disease, peptic ulcer, and renal impairment
  • In case of overdose, severe cardiac arrhythmias and tonic-clonic seizure may occur
  • Therapeutic class: Bronchodilator, Methyl xanthine derivatives
  • Storage conditions: Keep in a dry place away from light and heat. Keep out of the reach of children. Should be used only on prescription of a specialist physician

Indications

  • Treats bronchial asthma
  • Treats bronchospasm
  • Treats chronic obstructive pulmonary disease (COPD)
  • Treats pulmonary disease with spastic bronchial component

Pharmacology

  • Selectively inhibits phosphodiesterase 4 to relax bronchial smooth muscle
  • Differs from Theophylline due to the presence of a dioxolane group in position 7
  • Decreased affinities toward adenosine A1 and A2 receptors
  • Inhibits platelet activating factor (PAF) and generation of leukotriene production

Dosage and administration

  • Elderly: 200 mg tablet two or three times daily
  • Adults: 400 mg tablet two or three times daily
  • Children: dosage varies based on age and body weight
  • If required daily dose is 400 mg, Doxophylline SR tablet can be taken once daily or as prescribed by the physician

Interaction

  • Should not be administered with other xanthine preparations
  • Caution advised with ephedrine or other sympathomimetic drugs
  • Concurrent administration of certain drugs may reduce hepatic clearance of xanthine derivatives
  • Certain factors such as age, congestive cardiac decompensation, chronic obstructive pulmonary disease, severe liver disease, concomitant infections, and the administration of specific drugs may reduce the hepatic clearance of xanthine derivatives

Contraindications

  • Known hypersensitivity to the drug or other xanthine derivatives
  • Acute myocardial infarction
  • Hypotension
  • During lactation

Side effects

  • Nausea
  • Vomiting
  • Epigastric pain
  • Headache
  • Irritability
  • Insomnia
  • Tachycardia
  • Extrasystoles
  • Tachypnea
  • Hyperglycemia
  • Albuminuria
  • Severe cardiac arrhythmias
  • Tonic-clonic seizure

Pregnancy and lactation

  • Caution advised during pregnancy
  • Contraindicated during lactation
  • Animal tests have shown that the active ingredient does not interfere with pre and postnatal growth
  • Insufficient clinical evidence about the effects of the drug during pregnancy

Precautions and warnings

  • Monitoring of blood levels of the drug is recommended for the control of the therapeutic range
  • Caution advised for patients with cardiac disease, hypertension, hypoxemia, hyperthyroidism, chronic corpulmonale, congestive heart failure, liver disease, peptic ulcer, and renal impairment
  • No risk of addiction or any other form of dependence

Overdose effects

  • Severe cardiac arrhythmias
  • Tonic-clonic seizure
  • No specific antidote

Therapeutic class

  • Bronchodilator
  • Methyl xanthine derivatives

Storage conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children
  • Should be used only on prescription of a specialist physician

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