Loxetine 30 mg (Tablet (Delayed Release))

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Duloxetine hydrochloride
Company Aci limited
Also available as
Loxetine 20 mg tablet

Indications

  • Major Depressive Disorder (MDD)
  • Generalized Anxiety Disorder (GAD)
  • Diabetic Peripheral Neuropathic Pain (DPNP)
  • Fibromyalgia
  • Chronic Musculoskeletal Pain

Pharmacology

Selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration. Less potent inhibitor of dopamine reuptake. No significant affinity for various receptors. Does not inhibit monoamine oxidase. Well absorbed. Elimination is mainly through hepatic metabolism.

Dosage & Administration

  • Major Depressive Disorder (MDD):
    • Starting Dose: 40 mg/day to 60 mg/day
    • Target Dose: Acute: 40 mg/day (20 mg twice daily) to 60 mg/day (once daily or as 30 mg twice daily); Maintenance: 60 mg/day
    • Maximum Dose: 120 mg/day
  • Generalized Anxiety Disorder (GAD):
    • Starting Dose: 60 mg/day
    • Target Dose: 60 mg/day (once daily)
    • Maximum Dose: 120 mg/day
  • Diabetic Peripheral Neuropathic Pain (DPNP):
    • Starting Dose: 60 mg/day
    • Target Dose: 60 mg/day (once daily)
    • Maximum Dose: 60 mg/day
  • Fibromyalgia:
    • Starting Dose: 30 mg/day
    • Target Dose: 60 mg/day (once daily)
    • Maximum Dose: 60 mg/day
  • Chronic Musculoskeletal Pain:
    • Starting Dose: 30 mg/day
    • Target Dose: 60 mg/day (once daily)
    • Maximum Dose: 60 mg/day
  • Additional Information: Some patients may benefit from starting at 30 mg once daily. No evidence that doses greater than 60 mg/day confer additional benefit. Gradual dose reduction recommended to avoid discontinuation symptoms.

Interaction

Metabolized by CYP1A2 and CYP2D6 isozymes. Co-administration with potent CYP1A2 inhibitors may increase Loxetine levels. Concomitant use with potent CYP2D6 inhibitors may result in higher concentrations of Loxetine.

Contraindications

  • Known hypersensitivity to the drug or any inactive ingredients
  • Not approved for treating bipolar depression
  • Patients with substantial alcohol use or evidence of chronic liver disease
  • Cautious use in patients with controlled narrow-angle glaucoma

Side Effects

  • Nausea
  • Dizziness
  • Dry mouth
  • Constipation
  • Decreased appetite
  • Fatigue
  • Somnolence
  • Increased sweating
  • Hyperhidrosis
  • Asthenia
  • Slight increase in blood pressure

Pregnancy & Lactation

  • Pregnancy: Category C. Use during pregnancy only if potential benefit justifies potential risk to the fetus.
  • Labor and Delivery: Effect on labor and delivery in humans is unknown. Use only if potential benefit justifies potential risk to the fetus.
  • Lactation: Unknown excretion of Duloxetine into human milk, nursing not recommended

Precautions & Warnings

  • Close monitoring of patients being treated with antidepressants
  • Cautioned about the risk of bleeding with concomitant use of Loxetine and drugs affecting coagulation
  • Cautiously used in patients with a history of mania or seizure disorder

Use in Special Populations

  • Pediatric Population: Safety and efficacy not established

Overdose Effects

Limited clinical experience with Loxetine overdose. No specific antidote. General measures employed in the management of overdose. Gastric lavage and activated charcoal may be indicated if performed soon after ingestion or in symptomatic patients.

Therapeutic Class

Serotonin-norepinephrine reuptake inhibitor (SNRI)

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.

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