Pricard 2.5 mg (Tablet)

Unit Price: ৳ 4.00 (50's pack: ৳ 200.00)

Medicine Details

Category Details
Generic Ramipril
Company The white horse pharmaceuticals ltd

Indications

  • Hypertension
  • Congestive heart failure
  • Acute myocardial infarction
  • Glomerular or incipient nephropathy
  • Reduction in the risk of myocardial infarction
  • Stroke
  • Cardiovascular death
  • Increased cardiovascular risk

Pharmacology

  • Angiotensin converting enzyme (ACE) inhibitor
  • Blocks the conversion of angiotensin I to angiotensin II
  • Decreased vasopressor activity
  • Decreased aldosterone secretion
  • Antihypertensive activity
  • Management of heart failure
  • Reduction of the risk of stroke and myocardial infarction
  • Long acting and well tolerated

Dosage

  • Adjusted according to patient tolerance and response
  • Usual initial dose of 1.25-2.5 mg once daily for hypertension
  • Initial dose of 2.5 mg twice daily for congestive heart failure after myocardial infarction
  • Recommended dose of 2.5 mg once daily for prevention of major cardiovascular events

Administration

  • Tablets to be swallowed with sufficient liquid
  • Must not be chewed or crushed
  • Absorption not significantly affected by food
  • Can be taken before, during or after a meal

Interaction

  • Concomitant administration with diuretics may lead to serious hypotension
  • Concomitant therapy with lithium may increase serum lithium concentration
  • Reduction in BP may affect the ability to drive and operate machinery
  • NSAIDs may reduce the antihypertensive effect and cause deterioration of renal function

Contraindications

  • Hypersensitivity to ramipril or any other ACE inhibitor or excipients
  • History of angioedema
  • Concomitant use with sacubitril/valsartan therapy
  • Haemodynamically relevant renal artery stenosis
  • Hypotensive or haemodynamically unstable states
  • Concomitant use with certain medicines in patients with diabetes or moderate to severe renal impairment
  • During pregnancy
  • With angiotensin II receptor antagonists (AIIRAs) in patients with diabetic nephropathy
  • Concomitant use with extracorporeal treatments leading to contact of blood with negatively charged surfaces

Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Asthenia
  • Symptomatic hypotension
  • Cough
  • Nausea
  • Vomiting
  • Diarrhoea
  • Rash
  • Urticaria
  • Oliguria
  • Anxiety
  • Amnesia
  • Angioneurotic oedema
  • Anaphylactic reactions
  • Hyperkalaemia

Pregnancy & Lactation

  • Must not be taken during pregnancy
  • Pregnancy must be excluded before starting treatment
  • Pregnancy must be avoided in cases where treatment with ACE inhibitors is indispensable
  • Not recommended during breastfeeding

Precautions & Warnings

  • Use with caution in patients with impaired renal function
  • Use with caution in patients with hyperkalaemia
  • Use with caution in patients with hypotension
  • Use with caution in patients with impaired hepatic function

Use in Special Populations

  • Elderly: Consider reduced initial dose
  • Hepatic impairment: Initiate treatment under close medical supervision
  • Renal impairment: Adjust dosage based on creatinine clearance
  • Patients pretreated with a diuretic: Consider discontinuing or reducing diuretic dose before starting treatment

Overdose Effects

  • Excessive peripheral vasodilatation
  • Marked hypotension
  • Bradycardia
  • Electrolyte disturbances
  • Renal failure

Therapeutic Class

  • Angiotensin-converting enzyme (ACE) inhibitors

Storage Conditions

  • Store at 30°C or below
  • Protect from light
  • Keep out of the reach of children
  • Do not use later than the date of expiry
  • To be dispensed only on the prescription of a registered physician

Related Brands