Lucza 150 mg (Capsule)

Unit Price: ৳ 22.15 (1 x 10: ৳ 221.48)
Strip Price: ৳ 221.48

Medicine Details

Category Details
Generic Fluconazole
Company Beacon pharmaceuticals plc
Also available as
Lucza 50 mg capsule Lucza 200 mg injection

Indications

  • Vaginal Candidiasis
  • Oropharyngeal Candidiasis
  • Oesophageal Candidiasis
  • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
  • Kerion
  • Pityriasis versicolor
  • Onychomycosis
  • Invasive candidal infections and cryptococcal infections
  • Prevention of cryptococcal meningitis
  • Prevention of fungal infections in immunocompromised patients
  • Systemic Candidiasis and Cryptococcal infection
  • Fungal urinary tract infections
  • Disseminated candidiasis
  • Prophylaxis for fungal infection in neutropenic cancer patients
  • Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis

Pharmacology

Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes responsible for the synthesis of ergosterol.

Dosage & Administration

  • Adults:
    • Vaginal Candidiasis: 150 mg as a single dose
    • Oropharyngeal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14 days
    • Oesophageal Candidiasis: 200 mg in 1st day followed by 100 mg daily for 14-30 days
    • Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea: 150 mg weekly for 4-6 weeks
    • Kerion: 50 mg daily for 20 days
    • Pityriasis versicolor: 400 mg as a single dose
    • Onychomycosis: 150 mg weekly for 12 months
    • Invasive candidal infections and cryptococcal infections (including meningitis): Orally or by IV infusion, 400 mg on first day then 200-400 mg daily
    • Prevention of cryptococcal meningitis: Orally or by IV infusion 200 mg daily
    • Prevention of fungal infections in immunocompromised patients: Orally or by IV infusion, 50-400 mg daily
  • Child over 1 year:
    • In Superficial Candidiasis: 1-2 mg/kg daily
    • In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
  • Use in Specific Population:
    • Elderly patient: Use normal dose if no evidence of renal impairment
    • Renal Impairment: Adjust dosage based on creatinine clearance

Interaction

  • Warfarin
  • Oral sulphonyl ureas
  • Hydrochlorothiazide
  • Phenytoin
  • Rifampicin
  • Oral contraceptives
  • Cyclosporin
  • Cimetidine
  • Antacids
  • Theophyline

Contraindications

Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds.

Side Effects

  • Nausea
  • Abdominal discomfort
  • Diarrhoea
  • Flatulence
  • Rash
  • Anaphylaxis

Pregnancy & Lactation

Fluconazole should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed.

Precautions & Warnings

  • Abnormalities of hepatic, renal, haematological and other biochemical function tests
  • Hepatic necrosis
  • Exfoliative cutaneous reactions
  • Use during lactation not recommended

Use in Special Populations

  • Use in the elderly: Use normal dose if no evidence of renal impairment
  • Use in renal impairment: Adjust dosage based on creatinine clearance

Overdose Effects

In the event of overdosage, supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate.

Therapeutic Class

Drugs for subcutaneous and mycoses

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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