Xovir 200 mg (Tablet)
Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Acyclovir oral |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- The treatment of viral infections due to Herpes simplex virus (type I & II) and Varicella zoster virus (herpes zoster & chicken pox)
- The treatment of Herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes and herpes labialis
- The prophylaxis of Herpes simplex infections in immunocompromised patients
Pharmacology
- Synthetic purine derivative
- Interferes with DNA synthesis
- Inhibits viral replication
- Converted to Aciclovir Triphosphate
- Peak plasma concentrations usually occur within 1.5-2 hours after oral administration
- Widely distributed into body tissues and fluids
- Excreted through the kidney by the glomerular filtration & tubular secretion
Dosage & Administration
- Treatment of initial herpes simplex: 200 mg 5 times daily usually for 5 days
- For immunocompromised patients: Adult: 400 mg 5 times daily for 5 days, longer if new lesions appear during treatment or if healing is incomplete; increase dose to 800 mg 5 times daily for genital herpes in immunocompromised
- Prevention of recurrence of herpes simplex: Adult: 200 mg 4 times daily or 400 mg twice daily possibly reduced to 200 mg 2 or 3 times daily and interrupted every 6-12 months
- Prophylactic treatment of herpes simplex in the immunocompromised patients: Adult: 200 to 400 mg 4 times daily
- Treatment of vericella (chicken pox): Adult and children over 40 kg: 800 mg 4 times daily for 5 days
- Treatment of herpes zoster (Shingles): 800 mg 5 times daily for 7 days
- Treatment of initial rectal (Proctitis) herpes infections: An oral Aciclovir dosage of 400 mg 5 times daily for 10 days or until clinical resolution occurs has been recommended
Interaction
- Probenecid reduces Aciclovir excretion and increases plasma concentration and risk of toxicity
Contraindications
- Hypersensitivity to Aciclovir
Side Effects
- Rash
- Gastrointestinal disturbance
- Rise in bilirubin and liver-related enzymes
- Increase in blood urea and creatinine
- Decrease in hematological indices
- Headache
- Neurological reaction
- Fatigue
Pregnancy & Lactation
- Pregnancy category B
- Caution should be exercised when it is administered to a nursing mother
Precautions & Warnings
- Administered with caution in patients with renal impairment
- Doses should be adjusted according to creatinine clearance
- Monitor neutrophil count at least twice weekly in neonates
Therapeutic Class
- Herpes simplex & Varicella-zoster virus infections
Storage Conditions
- Should be stored below 25°C
- Protected from light and moisture
- Keep out of the reach of children