Fabetor 90 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Etoricoxib |
| Company | Pharmacil limited |
| Also available as |
Title
Fabetor 90 mg Tablet
Categories
- Pain Relief
- Arthritis Medication
- NSAIDs
Description
Fabetor 90 mg Tablet is a selective COX-2 inhibitor indicated for the symptomatic relief of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute gouty arthritis, and moderate pain associated with dental surgery. It is orally active and decreases clinical signs and symptoms with decreased potential for gastrointestinal toxicity and effects on platelet aggregation.
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Acute gouty arthritis
- Moderate pain associated with dental surgery
Pharmacology
Etoricoxib is a potent, orally active cyclooxygenase-2 (COX-2) specific inhibitor that decreases clinical signs and symptoms without inhibiting COX-1, primarily responsible for pain, inflammation, and fever.
Dosage and administration
- Osteoarthritis: 30 mg once daily, increased to 60 mg if needed
- Rheumatoid arthritis: 90 mg once daily
- Ankylosing spondylitis: 90 mg once daily
- Acute gouty arthritis: 120 mg once daily for 8 days
- Postoperative dental surgery pain: 90 mg once daily, maximum of 3 days
Interactions
- Medicine:
- Oral anticoagulants
- Diuretics, ACE inhibitors, and Angiotensin II Antagonists
- Acetylsalicylic Acid
- Ciclosporin and tacrolimus
- Lithium
- Food and others: Take without regards to meals
Contraindications
- Hypersensitivity to the active substance or excipients
- Active peptic ulceration or gastrointestinal bleeding
- Pregnancy and lactation
- Severe hepatic or renal dysfunction
- Children and adolescents under 16 years of age
- Inflammatory bowel disease
- Congestive heart failure
- Uncontrolled hypertension
- Established cardiovascular diseases
Side effects
- Palpitation
- Fatigue
- Influenza-like symptoms
- Dry mouth
- Taste disturbance
- Atrial fibrillation
- Chest pain
- Cough
- Anxiety
- Myalgia
- Arthralgia
- Confusion
- Hallucinations
Pregnancy and lactation
Not recommended in women attempting to conceive, excreted in the milk of lactating rats
Precautions and warnings
- NSAID risk: Elderly and prior history of gastrointestinal disease
- Cardiovascular risk: Patients with significant risk factors for cardiovascular events
- Renal function: Monitoring of renal function
- Cardiac conditions: History of cardiac failure, left ventricular dysfunction, or hypertension
- Liver monitoring: Monitoring liver function, discontinue if signs of hepatic insufficiency occur
- Hypersensitivity occurrence: Discontinue at the first appearance of hypersensitivity signs
- Other concerns: May mask fever and signs of inflammation
Overdose effects
Administration of single doses up to 500 mg and multiple doses up to 150 mg/day did not result in significant toxicity
Therapeutic class
Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage conditions
Store below 30°C, protect from light & moisture, keep out of reach of children
Chemical structure
Molecular Formula: C18H15ClN2O2S
Common questions
- Duration of effect: 20-24 hours
- Onset of action: 1-2 hours, faster without food
- Habit forming: No
- Alcohol safety: Unsafe
- Driving safety: May affect alertness, avoid driving
- Kidney function: Caution, dose adjustment may be needed
- Liver function: Caution, dose adjustment may be needed