Frenvas 20 mg (Tablet)

Unit Price: ৳ 20.06 (3 x 7: ৳ 421.26)
Strip Price: ৳ 140.42

Medicine Details

Category Details
Generic Atorvastatin calcium
Company Radiant pharmaceuticals ltd
Also available as
Frenvas 10 mg tablet Frenvas 40 mg tablet

Indications

  • Reduce elevated total cholesterol levels
  • Reduce LDL cholesterol levels
  • Reduce apolipoprotein B levels
  • Reduce triglycerides levels
  • Treat heterozygous and homozygous familial hypercholesterolaemia
  • Treat mixed dyslipidemia
  • Treat hypertriglyceridaemia
  • Treat dysbetalipoproteinaemia
  • Reduce cardiac ischaemic events
  • Treat hypercholesterolemia associated with diabetes mellitus or renal transplantation

Pharmacology

  • Selective inhibitor of HMG-CoA reductase
  • Lowers plasma cholesterol and lipoprotein levels
  • Inhibits cholesterol synthesis in the liver
  • Increases hepatic LDL receptors for enhanced uptake of LDL
  • Rapidly absorbed after oral administration
  • Extensively metabolized to active metabolites
  • Eliminated primarily in bile
  • Has a plasma elimination half-life of approximately 14 hours

Dosage & Administration

  • Adult dosage: 10 mg to 80 mg once daily
  • Pediatric dosage: 10 mg to 20 mg once daily
  • Initial dosage may be increased at intervals of at least 4 weeks
  • Recommended starting dose of 10 mg to 20 mg once daily
  • Analysis of lipid levels within 2 to 4 weeks after initiation of treatment

Interaction

  • Increased risk of myopathy with concurrent use of certain drugs
  • Plasma concentration changes when coadministered with antacids, colestipol, digoxin, erythromycin, oral contraceptives, warfarin

Contraindications

  • Hypersensitivity to any component of the medication
  • Active liver disease
  • Unexplained persistent elevations of serum transaminases
  • History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side Effects

  • Constipation
  • Flatulence
  • Dyspepsia
  • Abdominal pain
  • Infection
  • Headache
  • Back pain
  • Rash
  • Asthenia
  • Arthralgia
  • Myalgia

Pregnancy & Lactation

  • Atorvastatin contraindicated during pregnancy
  • No established safety in pregnant women
  • Animal studies show toxicity to reproduction
  • Not known if excreted in human milk
  • Should not be used during breastfeeding

Precautions & Warnings

  • Liver function tests should be performed before initiation of treatment
  • Discontinue therapy if markedly elevated CPK levels occur or myopathy is diagnosed or suspected
  • Use with caution in patients with substantial alcohol consumption or history of liver disease

Use in Special Populations

  • Higher plasma concentrations in elderly subjects
  • No clinically significant difference in LDL-C reduction between men and women
  • No dose adjustment necessary in renal dysfunction
  • No significant clearance enhancement with hemodialysis
  • Markedly increased plasma concentrations in patients with chronic alcoholic liver disease

Overdose Effects

  • No specific treatment available
  • Symptomatic and supportive measures should be instituted
  • Liver function tests and serum CK levels should be monitored

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C33H35FN2O5

Common Questions about Frenvas 20 mg Tablet

  • Used to avoid heart attacks and Primary Hypercholesterolemia
  • Taken by mouth once daily, with or without food
  • Used for the treatment of Mixed Dyslipidemia and Hypertriglyceridemia
  • Possible side-effects include cough, muscle pain, breathing difficulty, and running nose
  • Should be stored at room temperature, away from heat and direct light
  • Classified as a statin and helps in decreasing the level of lipids or fats in the blood
  • Can slightly affect blood sugar levels in type 2 diabetes patients
  • Should be taken for the duration prescribed by a doctor and considered safe for long term use if taken as directed
  • Does not cause weight loss or thinning of the blood
  • Not recommended for use in children under 10 years old
  • Quick tips for safe usage

Antacid Interaction

When atorvastatin and antacid suspension were coadministered, plasma concentrations of atorvastatin decreased approximately 35%

Colestipol Interaction

Plasma concentrations of atorvastatin decreased approximately 25% when colestipol and atorvastatin were coadministered

Digoxin Interaction

When multiple doses of atorvastatin and digoxin were coadministered, steady-state plasma digoxin concentrations increased by approximately 20%

Erythromycin Interaction

In healthy individuals, plasma concentrations of atorvastatin increased approximately 40% with coadministration of atorvastatin and erythromycin, a known inhibitor of cytochrome P450 3A4

Oral Contraceptives Interaction

Coadministration of atorvastatin and an oral contraceptive increased AUC values for norethindrone and ethinyl estradiol by approximately 30% and 20%

Warfarin Interaction

Frenvas had no clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment

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