Cilnivas 5 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cilnidipine |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- management of hypertension for end-organ protection
- useful in elderly patients
- useful in patients with diabetes and albuminuria
Pharmacology
- dihydropyridine calcium-channel blocker
- binds to dihydropyridine binding sites of L-type voltage dependent calcium channel
- inhibits Ca2+ influx across the cell membranes of vascular smooth muscle cells
- inhibits Ca2+ influx via N-type voltage dependent calcium channels in sympathetic nerve cell membrane
- causes vasodilation
- inhibits release of norepinephrine from sympathetic nerve terminals
- suppresses reflex increase in heart rate after blood pressure reduction
Dosage & Administration
- 5-10 mg once daily after breakfast for adults
- maximum dose of 20 mg once daily for adults
- safety in pediatric patients not established
- dose initiation with lowest possible dose for elderly
Interaction
- interacts with other anti-hypertensive medications
- interacts with antipsychotics causing hypotension
- interacts with quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, and erythromycin
Contraindications
- contraindicated in patients with known sensitivity to Cilnidipine or any excipients
- contraindicated in patients with cardiogenic shock, recent MI, acute unstable angina, and severe aortic stenosis
Side Effects
- dizziness
- flushing
- headache
- hypotension
- peripheral edema
- palpitations
- GI disturbances
- increased micturition frequency
- lethargy
- eye pain
- depression
Pregnancy & Lactation
- should not be administered to pregnant women or women with possibilities of being pregnant
- advisable to avoid administration to nursing mothers
- discontinuation advised if administration is indispensable
Precautions & Warnings
- administered with care in patients with serious hepatic dysfunction
- administered with care in patients with history of serious adverse reactions to calcium antagonists
- dosage should be gradually decreased during discontinuation under close observation
Therapeutic Class
- belonging to the class of calcium-channel blockers
Storage Conditions
- store below 30°C
- protected from light and moisture
- keep away from reach out of the children