Cilnivas 10 mg (Tablet)
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cilnidipine |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Management of hypertension for end-organ protection
- Useful in elderly patients and those with diabetes and albuminuria
- Increasingly used in patients with chronic kidney disease
Pharmacology
- Dihydropyridine calcium-channel blocker
- Binds to dihydropyridine binding sites of L-type voltage dependent calcium channel
- Inhibits Ca2+ influx across cell membranes of vascular smooth muscle cells
- Causes vasodilation and relaxes vascular smooth muscle
- Inhibits Ca2+ influx via N-type voltage dependent calcium channels in the sympathetic nerve cell membrane
- Suppresses reflex increase in heart rate after blood pressure reduction
Dosage & Administration
- Adults: 5-10 mg once daily after breakfast
- Maximum dose: 20 mg once daily
- Pediatric use: Safety not established
- Elderly use: Initiate therapy with lowest possible dose (5 mg)
Interaction
- Potential interactions with other anti-hypertensive drugs, antipsychotics, quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, and erythromycin
Contraindications
- Known sensitivity to Cilnidipine or any excipients
- Cardiogenic shock
- Recent MI or acute unstable angina
- Severe aortic stenosis
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Palpitations
- GI disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Depression
Pregnancy & Lactation
- Not to be administered in pregnant or potentially pregnant women
- Avoid administration to nursing mothers
- Instruct patients to discontinue lactation if administration is indispensable
Precautions & Warnings
- Administer with care in patients with serious hepatic dysfunction
- History of serious adverse reactions to calcium antagonists
- Gradually decrease dosage during discontinuation under close observation
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Store below 30°C
- Protect from light and moisture
- Keep away from reach of children