Doxofyl 200 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxophylline |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Treats bronchial asthma
- Treats bronchospasm
- Treats chronic obstructive pulmonary disease (COPD)
- Treats pulmonary disease with spastic bronchial component
Pharmacology
- Novel bronchodilator
- Structurally differs from Theophylline
- Selectively inhibits phosphodiesterase 4
- Relaxes bronchial smooth muscle
- Decreased affinities toward adenosine A1 and A2 receptors
- Inhibits platelet activating factor (PAF)
- Inhibits generation of leukotriene production
Dosage & Administration
- Elderly dosage: 200 mg tablet two or three times daily
- Adult dosage: 400 mg tablet two or three times daily
- Children dosage (>12 years of age): 10 ml syrup or 200 mg tablet two or three times daily
- Children dosage (6-12 years of age): 6-9 mg/kg body weight two times daily
- Doxophylline SR tablet for required daily dose of 400 mg
- Dosage to be as prescribed by the physician
Interaction
- Avoid administration with other xanthine preparations
- Limit consumption of caffeine-containing beverages and food
- Caution with ephedrine or other sympathomimetic drugs
- Concurrent administration with specific drugs may affect hepatic clearance
- Phenytoin and other anticonvulsants may increase clearance
- Cigarette smoking may increase clearance
Contraindications
- Known hypersensitivity to the drug or other xanthine derivatives
- Acute myocardial infarction
- Hypotension
- During lactation
Side Effects
- Nausea
- Vomiting
- Epigastric pain
- Headache
- Irritability
- Insomnia
- Tachycardia
- Extrasystoles
- Tachypnea
- Hyperglycemia (rare)
- Albuminuria (rare)
- Severe cardiac arrhythmias in case of overdose
- Tonic-clonic seizure in case of overdose
Pregnancy & Lactation
- Animal tests show no interference with pre and postnatal growth
- Use during pregnancy should be carefully evaluated case by case
- Contraindicated during lactation
- No effect on ability to drive and use machines
Precautions & Warnings
- Factors may reduce hepatic clearance
- Monitoring blood levels in certain cases
- Caution in patients with cardiac disease, hypertension, elderly, severe hypoxemia, hyperthyroidism, liver disease, renal impairment
- Particular caution in patients with congestive heart failure
- No risk of addiction or dependence
Overdose Effects
- Severe cardiac arrhythmias
- Tonic-clonic seizure
- Discontinuation of treatment may be required
- Symptomatic treatment of cardiovascular collapse in case of overdose
Therapeutic Class
- Bronchodilator
- Methyl xanthine derivatives
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
- Use only on prescription of specialist physician