Protace 5 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ramipril |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Title
- Protace (Ramipril) Tablet
Categories
- Antihypertensive Medication
- Cardiovascular Medication
- Angiotensin-Converting Enzyme (ACE) Inhibitor
Description
- Ramipril is an angiotensin converting enzyme (ACE) inhibitor
- Effective in the management of heart failure
- Reduces the risk of stroke, myocardial infarction, and death from cardiovascular events
- Well tolerated for long-term therapy
- Tablets must be swallowed with sufficient liquid
- Absorption not significantly affected by food
Dimensions
- Tablet size
Color Options
- Not applicable
Functions
- Lowers blood pressure
- Management of heart failure
- Reduction of the risk of stroke and cardiovascular events
- Blocks the conversion of angiotensin I to angiotensin II
- Decreases vasopressor activity and aldosterone secretion
Materials
- Active ingredient: Ramipril
Technical Specifications
- Dosage: 1.25-20 mg daily
- Dosage adjustment according to patient tolerance and response
- Initial dose for hypertension: 1.25-2.5 mg daily
- Initial dose for heart failure after myocardial infarction: 2.5 mg twice daily
- Usable in patients with renal impairment
Design Elements
- Tablet form
Usability Features
- Well tolerated and suitable for long-term use
- Can be taken before, during, or after a meal
- Tablets must not be chewed or crushed
Dosage
- Dosage adjustment according to patient tolerance and response
- Usual maintenance dosage in adults: 2.5-20 mg daily
- Usual maintenance dosage given as a single dose or in 2 divided doses daily
Administration
- Tablets must be swallowed with sufficient liquid
- Absorption not significantly affected by food
- Can be taken before, during, or after a meal
Interactions
- Concomitant administration with diuretics may lead to serious hypotension
- Concomitant therapy with lithium may increase serum lithium concentration
- NSAIDs may reduce the antihypertensive effect and cause deterioration of renal function
- Reduction in blood pressure may affect the ability to drive and operate machinery
- Interaction with alcohol
Contraindications
- Hypersensitivity to ramipril or any other ACE inhibitor
- History of angioedema
- Concomitant therapy with sacubitril/valsartan
- Hypotensive or haemodynamically unstable states
- Pregnancy
- Hemodynamically relevant renal artery stenosis
- Use of aliskiren-containing medicines in patients with diabetes or with moderate to severe renal impairment
- Use of angiotensin II receptor antagonists (AIIRAs) in patients with diabetic nephropathy
Side Effects
- Dizziness
- Headache
- Fatigue
- Asthenia
- Symptomatic hypotension
- Cough
- Nausea
- Vomiting
- Diarrhea
- Rash
- Urticaria
- Oliguria
- Anxiety
- Amnesia
- Angioneurotic edema
- Anaphylactic reactions
- Hyperkalemia
Pregnancy & Lactation
- Must not be taken during pregnancy
- Pregnancy must be avoided if treatment with ACE inhibitors is indispensable
- Not recommended during breastfeeding
Precautions & Warnings
- Use with caution in patients with impaired renal function, hyperkalemia, hypotension, and impaired hepatic function
Use in Special Populations
- Reduced initial dose for elderly patients
- Initiation in patients with hepatic impairment must be under close medical supervision
- Initiation in patients with renal impairment must be titrated according to individual tolerance and response
- Consideration for discontinuing diuretic in patients pretreated with a diuretic
Overdose Effects
- Excessive peripheral vasodilatation
- Marked hypotension
- Shock
- Bradycardia
- Electrolyte disturbances
- Renal failure
- Management through detoxification and administration of adrenergic agonists or angiotensin II
- Volume and salt substitution
Therapeutic Class
- Angiotensin-converting enzyme (ACE) inhibitors
Storage Conditions
- Store at 30°C or below
- Protect from light
- Do not use later than the date of expiry
- Dispensed only on the prescription of a registered physician