Moxidex 0.5%+0.1% (Ophthalmic Solution)

Indications

• Treatment of eye infections caused by susceptible microorganisms
• Prevention of inflammation and bacterial infection after eye surgery

Composition

• Each ml contains Moxifloxacin Hydrochloride BP equivalent to Moxifloxacin 5 mg
• Each ml contains Dexamethasone Sodium Phosphate USP equivalent to Dexamethasone Phosphate 1 mg

Pharmacology

• Moxifloxacin inhibits topoisomerase II and topoisomerase IV
• Dexamethasone is anti-allergic, anti-exudative and anti-proliferative

Dosage & Administration

• Instill 1 drop, 4 times a day, from 1 day before surgery until 15 days after surgery
• Instill the medication immediately after cataract surgery
• Instill the medication at least 15 minutes after LASIK refractive surgery
• Instill 1 drop, 4 times a day for up to 7 days in eye infections caused by susceptible microorganisms

Contraindications

• Hypersensitivity to quinolones or any components of the product
• Glaucoma and/or ocular disease causing thinning of the cornea or sclera
• Inflammation in the eye caused by virus, fungi or mycobacteria
• Epithelial herpes simplex keratitis, vaccinia, varicella, and other viral diseases of the cornea and conjunctiva
• Mycobacterial infection of the eye
• Fungal diseases of ocular structures

Side Effects

• Moxifloxacin: Conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort
• Dexamethasone: Visual acuity & field defects, cataract formation, secondary ocular infection, perforation of the globe

Pregnancy & Lactation

• Use during pregnancy only if potential benefit justifies potential risk to the fetus
• Caution advised when used in nursing women

Precautions & Warnings

• Discontinue use if allergic reaction occurs
• Prolonged steroid use may result in ocular hypertension and/or glaucoma
• Routine evaluation of intraocular pressure is necessary
• Topical corticosteroids may cause perforations in diseases causing thinning of the cornea or sclera
• Steroids may mask or enhance existing infection in acute purulent conditions of the eye

Use in Special Populations

• No change in dosage is required in elderly patients
• Efficacy and safety in pediatric patients not established

Overdose Effects

• No information available on overdosage with Moxidex in humans

Therapeutic Class

• Ophthalmic Steroid preparations

Storage Conditions

• Store in a cool place below 30°C, protected from light
• Use contents within 28 days of opening
• Discard after 28 days
• Keep out of reach of children

Related Brands

• Iventi-D 0.5%+0.1% (Ophthalmic Solution) - square-pharmaceuticals-plc
• Dexamox 0.5%+0.1% (Ophthalmic Solution) - aristopharma-ltd