Palotic 0.5 mg (Tablet)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Palonosetron |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Acute and delayed nausea and vomiting
- Uncontrolled nausea and vomiting
- Chemotherapy-induced nausea and vomiting (CINV)
- Radiotherapy-induced nausea and vomiting (RINV)
- Post-operative & Post-discharge nausea and vomiting (PONV & PDNV)
Pharmacology
- 5-HT3 receptor antagonist
- Serotonin antagonist
- Central and peripheral nervous system effect
- Linear dose-proportional pharmacokinetics
- Volume of distribution: 6.9-7.9 L/kg
- Metabolism via liver and kidney
- Excretion as unchanged drug in urine
Dosage & Administration
- Usual Adult tablet dosage: 0.5 mg daily
- Usual Adult IV dosage: 0.075 mg over 10 seconds
- Administration prior to chemotherapy and radiotherapy
- Children dosage: Single IV dose at 20 mcg/kg
Interactions
- Safe administration with corticosteroids, analgesics, antiemetics
- No significant pharmacokinetic interactions with metoclopramide
- Low potential for clinically significant drug interactions
Contraindications
- Hypersensitivity to the drug or its components
Side Effects
- Headaches
- Constipation
Pregnancy & Lactation
- Pregnancy category 'B'
- Unknown excretion in breast milk
Use in Special Populations
- No dosage adjustment in elderly patients
- Use in children: IV 20 mcg/kg, maximum 1.5 mg
- No dosage adjustment in impaired renal and hepatic function
Overdose Effects
- No known antidote
- Supportive care management
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Cool & dry place
- Protected from light