Ferinject 100 mg/2 ml (IV Injection or Infusion)

2 ml vial: ৳ 996.74

Medicine Details

Category Details
Generic Ferric carboxymaltose
Company Vifor international inc switzerland
Also available as
Ferinject 500 mg injection

Indications

  • Treatment of iron deficiency anaemia in adult patients with intolerance to oral iron or unsatisfactory response to oral iron
  • Treatment of iron deficiency anaemia in adult patients with non-dialysis dependent chronic kidney disease

Description

  • Colloidal iron (III) hydroxide in complex with Carboxymaltose
  • Carbohydrate polymer that releases iron

Dosage & Administration

  • Stepwise approach for determination of individual iron need
  • Calculation and administration of the iron dose(s)
  • Post-iron repletion assessments

Interaction

  • No formal drug interaction studies performed with Ferinject

Contraindications

  • Hypersensitivity to the active substance, to Ferric Carboxymaltose or any of its excipients
  • Known serious hypersensitivity to other parenteral iron products
  • Anaemia not attributed to iron deficiency
  • Evidence of iron overload or disturbances in the utilisation of iron

Side Effects

  • Infrequent and usually mild side effects
  • Nausea, headache, dizziness, hypertension, injection site reactions, alanine aminotransferase increased, hypophosphataemia, hypersensitivity, dysgeusia, tachycardia, hypotension, flushing, dyspnoea, dyspepsia, abdominal pain, constipation, diarrhea, Pruritus, urticaria, erythema, rash, myalgia, back pain, arthralgia, muscle spasms, Pyrexia, fatigue, chest pain, oedema peripheral, chills, aspartate aminotransferase increased, gamma glutamyl transferase increased, blood lactate dehydrogenase increased, blood alkaline phosphatase increased, anaphylactoid reactions, loss of consciousness, anxiety, phlebitis, syncope, presyncope, bronchospasm, flatulence, angioedema, pallor, face oedema, rigors, malaise, influenza like illness

Pregnancy & Lactation

  • No adequate and well-controlled trials in pregnant women
  • Careful benefit/risk evaluation required before use during pregnancy
  • Unlikely to represent a risk to the breast-fed child

Precautions & Warnings

  • Serious hypersensitivity reactions reported
  • Monitor patients for signs and symptoms of hypersensitivity
  • Monitor patients for signs and symptoms of hypertension
  • Laboratory test alterations possible

Use in Special Populations

  • Limit maximum daily injection dose in haemodialysis-dependent chronic kidney disease patients
  • Not recommended in children under 14 years

Overdose Effects

  • Excessive dosages may lead to accumulation of iron in storage sites
  • Monitoring of iron parameters such as serum ferritin and transferrin saturation may assist in recognising iron accumulation

Therapeutic Class

  • Parenteral Iron Preparations

Storage Conditions

  • Store in a cool (below 30°C) & dry place
  • Away from light
  • Do not freeze
  • Keep out of the reach of children

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