Stresin 30 mg (Capsule (Delayed Release))

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Duloxetine hydrochloride
Company Unimed unihealth pharmaceuticals ltd
Also available as
Stresin 20 mg dr capsule

Product title

  • Stresin

Therapeutic class

  • Serotonin-norepinephrine reuptake inhibitor (SNRI)

Indications

  • Major Depressive Disorder (MDD)
  • Generalized Anxiety Disorder (GAD)
  • Diabetic Peripheral Neuropathic Pain (DPNP)
  • Fibromyalgia
  • Chronic Musculoskeletal Pain

Pharmacology

  • Selective serotonin and norepinephrine reuptake inhibitor (SSNRI)
  • Less potent inhibitor of dopamine reuptake
  • Well absorbed
  • Mainly hepatic metabolism

Dosage and administration

  • MDD:
    • Starting Dose: 40 mg/day to 60 mg/day
    • Target Dose: Acute: 40 mg/day to 60 mg/day; Maintenance: 60 mg/day
    • Maximum Dose: 120 mg/day
  • GAD:
    • Starting Dose: 60 mg/day
    • Target Dose: 60 mg/day
    • Maximum Dose: 120 mg/day
  • DPNP:
    • Starting Dose: 60 mg/day
    • Target Dose: 60 mg/day
    • Maximum Dose: 60 mg/day
  • Fibromyalgia:
    • Starting Dose: 30 mg/day
    • Target Dose: 60 mg/day
    • Maximum Dose: 60 mg/day
  • Chronic Musculoskeletal Pain:
    • Starting Dose: 30 mg/day
    • Target Dose: 60 mg/day
    • Maximum Dose: 60 mg/day
  • Other:
    • Some patients may benefit from starting at 30 mg once daily
    • No evidence for doses greater than 60 mg/day conferring additional benefit
    • Gradual dose reduction recommended to avoid discontinuation symptoms

Interaction

  • Metabolism involving CYP1A2 and CYP2D6 isozymes
  • Effects of co-administration with inhibitors of CYP1A2 and CYP2D6

Contraindications

  • Hypersensitivity to the drug or inactive ingredients
  • Unapproved for treating bipolar depression
  • Not recommended for patients with substantial alcohol use or chronic liver disease
  • Caution in patients with controlled narrow-angle glaucoma

Side effects

  • Nausea
  • Dizziness
  • Dry mouth
  • Constipation
  • Decreased appetite
  • Fatigue
  • Somnolence
  • Increased sweating
  • Hyperhidrosis
  • Asthenia
  • Slight increase in blood pressure
  • No clinically significant differences in heart intervals observed

Pregnancy and lactation

  • Pregnancy: Pregnancy Category C; use only if benefits outweigh risks
  • Labor and delivery: Effects unknown; use only if benefits outweigh risks
  • Lactation: Unknown if excreted into human milk; not recommended during nursing

Precautions and warnings

  • Close monitoring for clinical worsening and unusual changes in behavior during initial months of therapy
  • Blood pressure measurement prior to treatment and periodically throughout
  • Caution for bleeding risk when used with certain drugs
  • Use cautiously in patients with a history of mania or seizure disorder

Use in special populations

  • Pediatric population: Safety and efficacy not established

Overdose effects

  • Limited clinical experience with overdose
  • No specific antidote
  • General measures for managing overdose recommended
  • Caution in inducing emesis
  • Activated charcoal may be useful in limiting absorption

Storage conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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