Alton 40 mg/vial (IV Injection)

40 mg vial: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company General pharmaceuticals ltd
Also available as
Alton 20 mg tablet Alton 40 mg tablet

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of acid-related Dyspepsia
  • Healing of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Specific inhibition of the H+/K+-ATPase
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Extensively metabolized in the liver by the cytochrome P450 enzyme system

Dosage

  • Oral dosage form for various conditions
  • IV Injection and IV infusion for specific patient groups

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension administration and IV Injection instructions

Interactions

  • Metabolism by CYP2C19 and CYP3A4
  • No clinically relevant interactions with specific drugs
  • Potential interference with CYP2C19 and gastric pH-dependent drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion in milk not studied
  • Discontinuation of breast-feeding if essential use is considered

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients with difficulty swallowing capsules

Use in Special Populations

  • Safety and effectiveness not established in paediatric patients
  • No overall differences in safety and efficacy observed in the elderly
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in renal impairment

Overdose Effects

  • Signs of acute toxicity in animal studies
  • No specific antidote known
  • Expected protein binding limits removal by dialysis
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image URL

Common Questions about Alton 40 mg/vial Injection

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