Hexiphen 2 mg (Tablet)
Unit Price: ৳ 5.50 (5 x 10: ৳ 275.00)
Strip Price: ৳ 55.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct in the treatment of parkinsonism
- Useful as adjuvant therapy with levodopa
- Control of extrapyramidal disorders
- Treatment of symptoms associated with Parkinson’s disease
Description
- Exerts direct inhibitory effect upon the parasympathetic system
- Relaxing effect on smooth musculature
- Inhibitory effect on the parasympathetic nervous system
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Binds with higher affinity to M1 subtype receptors
- Higher affinity for central muscarinic receptors in cerebral cortex
- Lower affinity for peripheral muscarinic receptors
- Modification of nicotinic acetylcholine receptor neurotransmission
- Enhanced dopamine release in the striatum
- Mechanism of action not fully elucidated
Dosage & Administration
- Individualized dosage
- Initial dose should be low and increased gradually, especially in patients over 60 years of age
- Dose adjustment based on patient reaction
- Distinct dosage recommendations for different types of parkinsonism
- Division of total daily intake into multiple doses
- Caution for use in pediatric patients
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with concurrent use of alcohol or other CNS depressants
- Intensification of anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
- Risk of tardive dyskinesia during concomitant administration of anticholinergics and neuroleptics
- Possible need to reduce dose of levodopa during concomitant therapy
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Exacerbation of parkinsonism with abrupt treatment withdrawal
- Neuroleptic malignant syndrome with abrupt treatment withdrawal
- Various rare side effects reported
Pregnancy & Lactation
- No controlled data in animal or human pregnancy
- Caution recommended during breastfeeding
- Possible suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to initiation of therapy
- Monitoring of intraocular pressures
- Potential for angle closure and increased intraocular pressure
- Caution in hot weather, especially with other atropine-like drugs
- Consideration of hyperthermia in the presence of anhidrosis
- Risk of Neuroleptic Malignant Syndrome
Overdose Effects
- Typical central symptoms of atropine intoxication
- Neuropsychiatric signs
- Progression to stupor, coma, paralysis, and death
- Treatment involves symptomatic and supportive therapy
- Gastric lavage or methods to limit absorption
- Administration of diazepam or short-acting barbiturate if CNS excitation is observed
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Protect from light