Methipred 500 mg/vial (IM/IV Injection)

Title

• Methipred IM/IV

Categories

• Medicine
• Pharmaceuticals
• Healthcare

Description

• Methylprednisolone, a glucocorticoid with anti-inflammatory effects
• Used for various conditions including endocrine, rheumatic, collagen, dermatological, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and miscellaneous disorders

Dosage and Administration

• Administered by IM or IV injection
• Recommended initial dosage varies from 10 to 40 mg depending on the clinical problem
• High-dose therapy may require 30 mg/kg administered intravenously over at least 30 minutes
• Pediatric initial dose varies depending on the specific disease being treated

Indications

• Primary or secondary adrenocortical insufficiency
• Acute adrenocortical insufficiency
• Rheumatoid arthritis
• Acute and subacute bursitis
• PSoriatic arthritis
• Ankylosing spondylitis
• Pemphigus
• Severe psoriasis
• Allergic states including asthma and dermatitis
• Severe acute and chronic allergic and inflammatory processes involving the eye
• Ulcerative colitis
• Tuberculosis
• Acquired hemolytic anemia
• Leukemias and lymphoma
• Nephrotic syndrome
• Tuberculous meningitis

Interaction

• Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression
• Concomitant use of corticosteroids and warfarin usually results in inhibition of response to warfarin
• Corticosteroids may increase blood glucose concentrations, requiring dosage adjustments of antidiabetic agents
• Corticosteroids may suppress reactions to skin tests
• Patients on prolonged corticosteroid therapy may exhibit a diminished response to vaccines

Contraindications

• Systemic fungal infections
• Known hypersensitivity to the product and its constituents
• Intramuscular corticosteroid preparations are contraindicated for idiopathic thrombocytopenic purpura

Side Effects

• Fluid and electrolyte disturbances
• Muscle weakness
• Peptic ulcer with possible perforation and hemorrhage
• Impaired wound healing
• Increased intracranial pressure
• Development of Cushingoid state
• Posterior subcapsular cataracts
• Negative nitrogen balance due to protein catabolism

Pregnancy and Lactation

• Corticosteroids have been shown to be teratogenic in many species when given in doses equivalent to the human dose
• Systemically administered corticosteroids appear in human milk

Precautions and Warnings

• Sensitive to heat
• Lowest possible dose should be used to control the condition
• Complications of treatment with glucocorticoids are dependent on the size of the dose and the duration of treatment
• Pediatric patients may experience a decrease in their growth velocity

Use in Special Populations

• Pediatric patients should be carefully observed with frequent measurements
• Elderly patients may respond differently and should start at the low end of the dosing range

Therapeutic Class

• Glucocorticoids

Reconstitution

• Directions for reconstitution provided

Storage Conditions

• Protect from light
• Store at controlled room temperature 20°C to 25°C

Related Brands

• Solu-Medrol 125 mg/vial (IM/IV Injection) - pfizer
• Solu-Medrol 40 mg/vial (IM/IV Injection) - pfizer
• Depomed 500 mg/vial (IM/IV Injection) - drug-international-ltd