Nebipres 5 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Nebivolol hydrochloride
Company General pharmaceuticals ltd
Also available as
Nebipres 25 mg tablet

Indications

  • Hypertension
  • Treatment of essential hypertension
  • Chronic heart failure (CHF)
  • Treatment of stable mild and moderate chronic heart failure in addition to standard therapies in elderly patients.

Pharmacology

  • β adrenergic receptor blocking agent
  • inhibits both β1 and β1 adrenergic receptors
  • lacks intrinsic sympathomimetic and membrane stabilizing activity
  • decreased heart rate
  • decreased myocardia contractility
  • diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers
  • suppression of renin activity
  • vasodilation and decreased peripheral vascular resistance
  • metabolized by glucuronidation and hydroxylation by CYP2D6
  • absorption similar to an oral solution
  • plasma protein binding of approximately 98%
  • metabolized via direct glucuronidation of parent
  • excretion via urine and feces

Dosage & Administration

  • Recommended starting dose of 5 mg once daily
  • dose can be increased at 2-week intervals up to 40 mg
  • more frequent dosing regimen unlikely to be beneficial

Interaction

  • Use with care when myocardial depressants or inhibitors of AV conduction are used concurrently
  • not to be combined with other β-blockers
  • use caution when co-administered with CYP2D6 inhibitors

Contraindications

  • Severe bradycardia
  • heart block greater than first degree
  • cardiogenic shock
  • decompensated cardiac failure
  • sick sinus syndrome (unless a permanent pacemaker is in place)
  • severe hepatic impairment
  • hypersensitivity to any component of this product

Side Effects

  • Headache
  • nausea
  • bradycardia

Precautions & Warnings

  • Abrupt Cessation of Therapy
  • Cardiac Failure
  • Angina and Acute Myocardial Infarction
  • Bronchospastic Diseases
  • Anesthesia and Major Surgery
  • Diabetes and Hypoglycemia
  • Thyrotoxicosis
  • Peripheral Vascular Disease
  • Non-dihydropyridine Calcium Channel Blockers

Use in Special Populations

  • Impaired Renal Function
  • Impaired Hepatic Function
  • Risk of Anaphylactic Reactions

Therapeutic Class

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C temperature
  • away from light & moisture
  • Keep out of the reach of children

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