Toroaid 60 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 95.25 (1 x 5: ৳ 476.24)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company General pharmaceuticals ltd
Also available as
Toroaid 10 mg tablet Toroaid 30 mg injection Toroaid 05 eye drop

Indications

  • Moderate to severe acute post-operative pain management
  • Relief from pain, inflammation, and light sensitivity after ocular surgery
  • Decreasing eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical composition as 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid and 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Predominantly metabolized in the liver

Pharmacology

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Acts by inhibiting the cyclooxygenase enzyme system
  • Demonstrates minimal anti-inflammatory effect at its analgesic dose

Dosage & Administration

  • Recommended tablet dose of 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Injection may be used for acute pain management, with specific doses for different age and weight groups
  • Adults: 1 drop in each eye 4 times daily for eye drops

Interactions

  • Increases side effects with other NSAIDs or aspirin
  • Enhances anti-coagulant effect with anti-coagulants
  • Reduces the anti-hypertensive effect with Beta Blockers
  • Increases the risk of renal impairment with ACE Inhibitors
  • Enhances the toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic use before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastrointestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in female
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoid use in pregnancy and lactation unless benefits outweigh risks to the fetus

Precautions & Warnings

  • Caution in patients over 65 years
  • Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, or liver dysfunction
  • Discontinue use of topical NSAIDs in case of corneal epithelial breakdown

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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