Depomed 2 mg (Tablet)
Unit Price: ৳ 3.00 (5 x 10: ৳ 150.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Methylprednisolone |
| Company | Drug international ltd |
| Also available as |
Title
Depomed
Categories
- Medicine
- Pharmaceutical
Description
Potent anti-inflammatory steroid with greater anti-inflammatory potency than Prednisolone and less tendency to induce sodium and water retention.
Indications
- Primary or Secondary Adrenocortical Insufficiency
- Rheumatoid Arthritis
- Juvenile Rheumatoid Arthritis
- Systemic lupus Erythematosus
- Severe Psoriasis
- Allergic Rhinitis
- Bronchial Asthma
- Nephrotic Syndrome
- Ulcerative Colitis
- Multiple Sclerosis
Pharmacology
- Pharmacodynamic Properties: Potent anti-inflammatory agent with profound immune system inhibition
- Pharmacokinetic Properties:
- Bioavailability: 82-89% following oral administration
- Absorption: Rapid, with maximum plasma concentration achieved around 1.5-2.3 hours
- Distribution: Widely distributed into tissues, crosses the blood-brain barrier and placental barrier
- Metabolism: In the liver to inactive metabolites
- Protein Binding: Approximately 77%
- Excretion: Secreted in breast milk, haemodializable
DosageAndAdministration
- Usual Range: 2-48 mg daily in divided doses
- Initial Dosage: 4-48 mg per day, adjusted based on disease severity
- Maintenance Dosage: Adjusted to lowest effective dose
- Multiple Sclerosis Treatment: 160 mg daily for a week, followed by 64 mg every other day for 1 month
- Alternate-Day Therapy: Twice the usual daily dose administered every other morning
Interaction
- Inhibitors:
- Erythromycin
- Clarithromycin
- Phenobarbital
- Phenytoin
- Rifampin
- Ketoconazole
- Enhancers:
- Estrogens
- Oral Contraceptives
Contraindications
- Systemic fungal infections
- Known hypersensitivity to components
SideEffects
- Fluid Retention
- Weight Gain
- High Blood Pressure
- Potassium Loss
- Headache
- Muscle Weakness
- Growth Retardation in Children
- Psychic Disturbances
PregnancyAndLactation
Pregnancy category C. Should be given only if the potential benefit justifies the potential risk to the fetus
PrecautionsAndWarnings
- Adrenocortical insufficiency may persist for months after discontinuation of therapy
- Enhanced effect on patients with hypothyroidism
- Cautious use in patients with ocular herpes simplex
- Careful observation of infants' and children's growth and development
OverdoseEffects
Rare reports of acute toxicity and death following an overdose, with no specific antidote available
TherapeuticClass
Glucocorticoids
StorageConditions
Cool and dry place, away from light, keep out of reach of children