Depomed 500 mg/vial (IM/IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Methylprednisolone sodium succinate |
| Company | Drug international ltd |
Title
Depomed IM/IV
Categories
- Medicine
- Pharmaceutical
Description
Depomed IM/IV is indicated in the following conditions: Endocrine disorder, Rheumatic disorder, Collagen disease, Dermatological disease, Allergic states, Ophthalmic disease, Gastrointestinal disease, Respiratory disease, Hematologic disorder, Neoplastic disease, Edematous state, Miscellaneous. Methylprednisolone, a naturally occurring glucocorticoid, is used for its potent anti-inflammatory effects. It may be administered by IM or IV injection. Contraindications include systemic fungal infections, hypersensitivity, and intrathecal administration. Side effects include fluid and electrolyte disturbances, musculoskeletal issues, gastrointestinal problems, dermatologic issues, neurological impacts, endocrine effects, ophthalmic complications, and others. It should be stored at controlled room temperature, protected from light, and used within 48 hours after mixing.
Indications
- Endocrine disorder
- Rheumatic disorder
- Collagen disease
- Dermatological disease
- Allergic states
- Ophthalmic disease
- Gastrointestinal disease
- Respiratory disease
- Hematologic disorder
- Neoplastic disease
- Edematous state
- Miscellaneous
Pharmacology
Methylprednisolone is primarily used for its potent anti-inflammatory effects in disorders of many organ systems. The intravenous injection of Methylprednisolone Sodium Succinate demonstrates effects within one hour and persist for a variable period. Its anti-inflammatory potency is greater than prednisolone in the ratio of 5 to 4. It influences various metabolic and functional capacities of the body.
Dosage & Administration
Methylprednisolone may be administered by IM or IV injection, prepared as directed. The dosage varies depending on the clinical problem being treated. High-dose corticosteroid therapy should be continued only until the patient’s condition has stabilized, usually not beyond 48 to 72 hours. Dosage must be decreased or discontinued gradually when the drug has been administered for more than a few days. In pediatric patients, dosage may vary depending on the specific disease being treated.
Interaction
- Aminoglutethimide
- Amphotericin B injection and potassium-depleting agents
- Macrolide antibiotics
- Anticholinesterases
- Anticoagulants, oral
- Antidiabetics
- Antitubercular drugs
- Cholestyramine
- Cyclosporine
- Digitalis glycosides
- Estrogens, including oral contraceptives
- Hepatic Enzyme Inhibitors
- Ketoconazole
- Nonsteroidal anti-inflammatory agents (NSAIDs)
- Skin tests
- Vaccines
Contraindications
- Systemic fungal infections
- Known hypersensitivity to the product and its constituents
- Intrathecal administration
- Idiopathic thrombocytopenic purpura
Side Effects
- Fluid and Electrolyte Disturbances
- Musculoskeletal issues
- Gastrointestinal problems
- Dermatologic complications
- Neurological impacts
- Endocrine effects
- Ophthalmic complications
- Others
Pregnancy & Lactation
Corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects.
Precautions & Warnings
Depomed is sensitive to heat and should not be autoclaved. The lowest possible dose of corticosteroid should be used to control the condition under treatment. Complications of treatment with glucocorticoids are dependent on the size of the dose and the duration of treatment, therefore a risk/benefit decision must be made in each individual case.
Use in Special Populations
- Pediatric Use
- Geriatric Use
Overdose Effects
Treatment of acute over dosage is by supportive and symptomatic therapy. For chronic over dosage in the face of severe disease requiring continuous steroid therapy, the dosage of the corticosteroid may be reduced only temporarily or alternate day treatment may be introduced.
Therapeutic Class
Glucocorticoids
Reconstitution
The powder for injection must be reconstituted to form a solution as directed, and should be aseptically administered.
Storage Conditions
Protect from light. Store at controlled room temperature 20° to 25°C. Use solution within 48 hours after mixing.