Doxoma 100 mg/5 ml (Syrup)
100 ml bottle: ৳ 95.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxophylline |
| Company | Drug international ltd |
| Also available as |
Indications
- Bronchial asthma
- Bronchospasm
- Chronic obstructive pulmonary disease (COPD)
- Pulmonary disease with spastic bronchial component
Pharmacology
- Novel bronchodilator
- Structurally differs from Theophylline
- Selectively inhibits phosphodiesterase 4
- Relaxes bronchial smooth muscle
- Decreased affinities toward adenosine A1 and A2 receptors
- Inhibits platelet activating factor (PAF)
- Inhibits leukotriene production
Dosage & Administration
- 200 mg tablet for elderly
- 400 mg tablet for adults
- 10 ml syrup for children >12 years of age
- 6-9 mg/kg body weight for children 6-12 years of age
- Doxophylline SR tablet for required daily dose of 400 mg
Interaction
- Avoid administering with other xanthine preparations
- Limit consumption of caffeine-containing beverages and food
- Exercise caution with ephedrine or other sympathomimetic drugs
- Concurrent administration with certain drugs may reduce hepatic clearance
Contraindications
- Known hypersensitivity to the drug or other xanthine derivatives
- Acute myocardial infarction
- Hypotension
- Lactation
Side Effects
- Nausea
- Vomiting
- Epigastric pain
- Headache
- Irritability
- Insomnia
- Tachycardia
- Extrasystoles
- Tachypnea
- Hyperglycemia (rare)
- Albuminuria (rare)
- Severe cardiac arrhythmias (overdose)
- Tonic-clonic seizure (overdose)
Pregnancy & Lactation
- Animal tests show no interference with pre and postnatal growth
- Clinical evidence of effects during pregnancy is insufficient
- Contraindicated during lactation
Precautions & Warnings
- Factors may reduce hepatic clearance of xanthine derivatives
- Monitoring of blood levels recommended for control of therapeutic range
- Caution in patients with cardiac disease, hypertension, hypoxemia, hyperthyroidism, and other conditions
- No risk of addiction or dependence
Overdose Effects
- Severe cardiac arrhythmias
- Tonic-clonic seizure
- Symptomatic treatment of cardiovascular collapse
Therapeutic Class
- Bronchodilator
- Methyl xanthine derivatives
Storage Conditions
- Dry place away from light and heat
- Keep out of reach of children
- Use only on prescription of specialist physician