Toposar 50 mg (Capsule)
Unit Price: ৳ 75.00 (4 x 7: ৳ 2,100.00)
Strip Price: ৳ 525.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Etoposide |
| Company | Drug international ltd |
| Also available as |
Indications
- Management of Small Cell Lung Cancer
- First-line treatment in patients with small cell lung cancer
Pharmacology
- Pharmacotherapeutic classification: podophyllotoxin derivatives
- Inhibition of mitosis by blocking microtubular assembly
- Inhibition of cell cycle progression at a premitotic phase
- Distribution half-life of about 1.5 hours
- Terminal elimination half-life ranging from 4 to 11 hours
- Total body clearance values range from 33 to 48 ml/min or 16 to 36 ml/min/m 2
- Linear increase in AUC and C_max values with dose
- Mean volumes of distribution at steady state fall in the range of 18 to 29 liters or 7 to 17 L/m^2
Dosage & Administration
- Dose ranges from 35 mg/m^2/day for 4 days to 50 mg/m^2/day for 5 days
- Initial dose modification based on measured creatinine clearance
- Subsequent dosing based on patient tolerance and clinical effect
- No data available in patients with creatinine clearances <15 ml/min
Interaction
- High-dose cyclosporine A affecting Toposar exposure and total body clearance
Contraindications
- Hypersensitivity to Etoposide or any component of the formulation
Side Effects
- Dose-related myelosuppression
- Nausea, vomiting, mucositis, and esophagitis
- Transient hypotension following rapid intravenous administration
- Anaphylactic-like reactions
- Reversible alopecia
- Other reported adverse reactions such as abdominal pain, fatigue, and rash
Pregnancy & Lactation
- Pregnancy category D
- Etoposide found in human milk
- Patients receiving Etoposide should not breastfeed
Precautions & Warnings
- Frequent observation for myelosuppression
- Dose-limiting bone marrow suppression
- Possible occurrence of anaphylactic reaction
- Administration by slow intravenous infusion
- Evaluation of the need and usefulness of the drug against the risk of adverse reactions
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Refrigeration at 2°C-8°C
- Stable for 24 months under refrigeration
- Protection from light
- Proper handling and disposal of anticancer drugs