Vorizol 200 mg/5 ml (Powder for Suspension)
Medicine Details
| Category | Details |
|---|---|
| Generic | Voriconazole |
| Company | Drug international ltd |
| Also available as |
Indications
- Invasive aspergillosis
- Candidemia
- Disseminated candidiasis
- Esophageal candidiasis
- Serious infections caused by Scedosporium apiospermum
- Fusarium species infections
- Patients intolerant of, or refractory to other therapy
Pharmacology
Voriconazole is a triazole antifungal medication used to treat serious fungal infections. It binds and inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase, resulting in depletion of ergosterol in fungal cell membrane.
Dosage & Administration
- Oral:
- To be taken at least one hour before or one hour following a meal
- Different dosage regimen based on body weight
- Injection:
- Invasive Aspergillosis:
- Loading dose: 6 mg/kg 12 hourly for the first 24 hours
- Maintenance Dose: 4 mg/kg 12 hourly
- Candidemia in nonneutropenic patients:
- Loading dose: 6 mg/kg 12 hourly for the first 24 hours
- Maintenance Dose: 3-4 mg/kg 12 hourly
- Scedosporiosis and Fusariosis:
- Loading dose: 6 mg/kg 12 hourly for the first 24 hours
- Maintenance Dose: 4 mg/kg 12 hourly
- Invasive Aspergillosis:
Interaction
- Adjust Vorizol dosage and monitor for adverse reactions or lack of efficacy with CYP3A4, CYP2C9, and CYP2C19 inhibitors and inducers
- Potential for Vorizol to increase concentrations and activity of drugs that are CYP3A4, CYP2C9, and CYP2C19 substrates
- Increase maintenance oral and intravenous dosage of Vorizol with co-administration of Phenytoin or Efavirenz
Contraindications
- Known hypersensitivity to Voriconazole or any other components of this drug
- Co-administration with specific drugs due to risk of serious adverse reactions or loss of efficacy
Side Effects
- Abdominal pain
- Anemia
- Blurred vision
- Headache
- Chest pain
- Nausea
- Diarrhea
Pregnancy & Lactation
No adequate and well-controlled studies in pregnant women; use during pregnancy only if potential benefit justifies the risk to the fetus
Precautions & Warnings
Careful assessment of the benefit-risk balance required for long term exposure; reported association with squamous cell carcinoma of the skin with long-term Vorizol treatment
Use in Special Populations
Efficacy in children under 12 years of age is not established
Overdose Effects
No data found about overdose of Voriconazole
Therapeutic Class
Other Antifungal preparations
Reconstitution
Reconstitution instructions for suspension provided; shelf life of reconstituted suspension
Storage Conditions
Keep out of reach of children; store in a dry place, below 25°C temperature and protected from light; specific storage conditions for Vorizol powder for suspension