Ramipress 1.25 mg (Tablet)

Unit Price: ৳ 2.51 (3 x 10: ৳ 75.30)
Strip Price: ৳ 25.10

Medicine Details

Category Details
Generic Ramipril
Company Silva pharmaceuticals ltd
Also available as
Ramipress 25 mg tablet Ramipress 5 mg tablet

Indications

  • Hypertension
  • Congestive heart failure
  • Treatment after acute myocardial infarction
  • Glomerular or incipient nephropathy
  • Risk reduction for myocardial infarction, stroke, or cardiovascular death

Pharmacology

  • Angiotensin converting enzyme (ACE) inhibitor
  • Decreased vasopressor activity
  • Decreased aldosterone secretion
  • Management of heart failure
  • Risk reduction for stroke, myocardial infarction, and death from cardiovascular events
  • Long-acting and well-tolerated

Dosage

  • Initial dose of 1.25-2.5 mg once daily for hypertension in adults
  • Maintenance dosage of 2.5-20 mg daily for hypertension
  • Initial dose of 2.5 mg twice daily for congestive heart failure after myocardial infarction
  • Prevention of major cardiovascular events dosage: 2.5 mg once daily for the first week, 5 mg once daily for the following 3 weeks, increased to 10 mg once daily as tolerated
  • Adjusted dosage for renal impairment

Administration

To be swallowed whole with liquid; absorption not affected by food

Interaction

  • Concomitant administration with diuretics may cause hypotension
  • Concomitant therapy with lithium may increase serum lithium concentration
  • BP reduction may affect ability to drive and operate machinery
  • NSAIDs may reduce the antihypertensive effect and cause deterioration of renal function

Contraindications

  • Hypersensitivity to ramipril or any other ACE inhibitor
  • History of angioedema
  • Concomitant use with sacubitril/valsartan therapy
  • Haemodynamically relevant renal artery stenosis
  • Hypotensive or haemodynamically unstable states
  • Concomitant use with aliskiren-containing medicines in patients with diabetes or with moderate to severe renal impairment
  • Concomitant use with angiotensin II receptor antagonists in patients with diabetic nephropathy
  • During pregnancy
  • Concomitant use with extracorporeal treatments leading to contact of blood with negatively charged surfaces

Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Symptomatic hypotension
  • Cough
  • Nausea
  • Vomiting
  • Diarrhoea
  • Rash
  • Urticaria
  • Oliguria
  • Anxiety
  • Amnesia
  • Angioneurotic oedema
  • Anaphylactic reactions
  • Hyperkalaemia

Pregnancy & Lactation

  • Must not be taken during pregnancy
  • Pregnancy must be excluded before starting treatment
  • Not recommended during breastfeeding

Precautions & Warnings

  • Use with caution in patients with impaired renal function
  • Use with caution in patients with hyperkalaemia
  • Use with caution in patients with hypotension
  • Use with caution in patients with impaired hepatic function

Use in Special Populations

  • Elderly: Consider reduced initial dose
  • Hepatic impairment: Initiate treatment under close medical supervision
  • Renal impairment: Consider reduced initial dose
  • Patients pretreated with a diuretic: Consider discontinuation of diuretic before starting treatment

Overdose Effects

  • Excessive peripheral vasodilatation
  • Marked hypotension
  • Shock
  • Bradycardia
  • Electrolyte disturbances
  • Renal failure

Therapeutic Class

Angiotensin-converting enzyme (ACE) inhibitors

Storage Conditions

Store at 30°C or below, protect from light, keep out of reach of children, do not use later than the date of expiry

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