Bredox 200 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxophylline |
| Company | Globe pharmaceuticals ltd |
| Also available as |
Indications
- Bronchial asthma
- Bronchospasm
- Chronic obstructive pulmonary disease (COPD)
- Pulmonary disease with spastic bronchial component
Pharmacology
- Doxophylline is a novel bronchodilator
- Inhibits phosphodiesterase 4
- Relaxes bronchial smooth muscle
- Selectively inhibits phosphodiesterase 4
- Decreased affinities toward adenosine A1 and A2 receptors
- Inhibits platelet activating factor (PAF) and generation of leukotriene production
Dosage & Administration
- Dosage for Elderly: 200 mg tablet two or three times daily
- Dosage for Adults: 400 mg tablet two or three times daily
- Dosage for Children (>12 years of age): 10 ml syrup or 200 mg tablet two or three times daily
- Dosage for Children (6-12 years of age): 6-9 mg/kg body weight two times daily
- Doxophylline SR tablet for required daily dose of 400 mg
Interaction
- Avoid administration with other xanthine preparations
- Limit consumption of beverages and food containing caffeine
- Use caution when combining with ephedrine or other sympathomimetic drugs
- Concurrent administration with erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine, and propanolol
- Phenytoin, other anticonvulsants, and cigarette smoking may affect clearance
- Possible dosage adjustment in case of interaction
Contraindications
- Known hypersensitivity to the drug or other xanthine derivatives
- Acute myocardial infarction
- Hypotension
- Lactation
Side Effects
- Nausea
- Vomiting
- Epigastric pain
- Headache
- Irritability
- Insomnia
- Tachycardia
- Extrasystoles
- Tachypnea
- Hyperglycemia
- Albuminuria
- Severe cardiac arrhythmias
- Tonic-clonic seizure
Pregnancy & Lactation
- Effects on pre and postnatal growth in animal tests
- Caution advised during pregnancy based on risk-benefit ratio
- Contraindicated during lactation
- No effect on patient's alertness for driving and using machines
Precautions & Warnings
- Factors affecting hepatic clearance
- Age-related factors
- Cardiac disease
- Hypertension
- Chronic obstructive pulmonary disease
- Severe liver disease
- Concomitant infections
- Monitoring of blood levels recommended
- Caution in patients with various health conditions
- No risk of addiction or dependence
Overdose Effects
- Severe cardiac arrhythmias
- Tonic-clonic seizure
- Discontinuation of treatment may be required
- Symptomatic treatment for cardiovascular collapse
Therapeutic Class
- Bronchodilator
- Methyl xanthine derivatives
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
- Use only on prescription of specialist physician