Afinitor 10 mg (Tablet)

Unit Price: ৳ 8,943.00 (3 x 10: ৳ 268,290.00)
Strip Price: ৳ 89,430.00

Medicine Details

Category Details
Generic Everolimus
Company Novartis bangladesh ltd
Also available as
Certican 025 mg tablet Certican 050 mg tablet Certican 075 mg tablet Afinitor 5 mg tablet

Title

  • Afinitor

Categories

  • Medicine
  • Pharmaceutical
  • Immunosuppressant

Description

  • Afinitor is indicated in advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer, Neuroendocrine Tumors, Renal Cell Carcinoma, Renal Angiomyolipoma With Tuberous Sclerosis Complex, Subependymal Giant Cell Astrocytoma, and for the prophylaxis of organ rejection in transplant patients.

Indications

  • Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer
  • Neuroendocrine Tumors
  • Renal Cell Carcinoma
  • Renal Angiomyolipoma With Tuberous Sclerosis Complex
  • Subependymal Giant Cell Astrocytoma
  • Organ rejection prophylaxis in transplant patients

ModeOfAction

  • Prevents allograft rejection
  • Inhibits proliferation of antigen-activated T cells
  • Forms complex with cytoplasmic protein FKBP-12
  • Inhibits FRAP function

DosageAdministration

  • Initial dose varies depending on transplant type
  • Recommended dose for indicated cancers is 10mg once daily
  • Administer consistently with or without food
  • Swallow whole with a glass of water

Interaction

  • CYP3A4 inhibitors &/or inducers
  • CYP2D6 substrates with narrow therapeutic index
  • PgP inhibitors
  • Rifampicin
  • ACE inhibitors
  • Grapefruit juice
  • Live vaccines

Contraindications

  • Hypersensitivity to the active substance or other rapamycin derivatives
  • Hypersensitivity reactions including anaphylaxis and angioedema

SideEffects

  • Stomatitis
  • Constipation
  • Infections
  • Asthenia
  • Fatigue
  • Cough
  • Diarrhea
  • Rash
  • Anemia
  • Nausea
  • Anorexia
  • Edema
  • Dyspnea
  • Pyrexia
  • Vomiting
  • Headache
  • Epistaxis
  • Decreased lymphocytes

PregnancyLactation

  • Pregnancy Category D
  • Positive evidence of human fetal risk
  • Not recommended during lactation

PrecautionsWarnings

  • Increased risk for angioedema with ACE inhibitor therapy
  • Monitor for interstitial lung disease/noninfectious pneumonitis
  • Increased risk for infections
  • Common side effect of mouth ulcers and stomatitis
  • May delay wound healing and increase wound-related complications

TherapeuticClass

  • Immunosuppressant

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