Docetaxel Axios 80 mg/vial (IV Infusion)

80 mg vial: ৳ 11,370.00

Medicine Details

Category Details
Generic Docetaxel trihydrate
Company Bots pvt limited
Also available as
Docetaxel axios 20 mg injection

Title

Docetaxel Axios

Categories

  • Chemotherapy
  • Antineoplastic Agent
  • Cytotoxic Chemotherapy

Description

Docetaxel Axios is a microtubule inhibitor indicated for various cancers such as Breast Cancer, Non-small Cell Lung Cancer, Prostate Cancer, Gastric Adenocarcinoma, and Squamous Cell Carcinoma of the Head and Neck.

Indications

  • Breast Cancer treatment
  • Non-small Cell Lung Cancer treatment
  • Prostate Cancer treatment
  • Gastric Adenocarcinoma treatment
  • Squamous Cell Carcinoma of the Head and Neck treatment

Mode of Action

Disrupts microtubular network, vital for cellular functions, promotes tubulin assembly, inhibits disassembly, binds to free tubulin, decreases intracellular tubulin concentration

Dosage & Administration

  • Administer intravenously
  • Premedicate with oral corticosteroids
  • Adjust dose as needed

Interaction

CYP3A4 substrate, metabolism may be modified by concomitant administration of compounds

Contraindications

  • Neutrophil counts <1500 cells/mm3
  • History of severe hypersensitivity reactions to docetaxel or other drugs formulated with polysorbate 80

Side Effects

  • Infections
  • Neutropenia
  • Anemia
  • Febrile neutropenia
  • Hypersensitivity
  • Thrombocytopenia
  • Neuropathy
  • Dysgeusia
  • Dyspnea
  • Constipation
  • Anorexia
  • Nail disorders
  • Fluid retention
  • Asthenia
  • Pain
  • Nausea
  • Diarrhea
  • Vomiting
  • Mucositis
  • Alopecia
  • Skin reactions
  • Myalgia

Pregnancy & Lactation

Can cause fetal harm when administered to a pregnant woman, no information on effects on milk production or breastfed child

Precautions & Warnings

  • Use under supervision of experienced physician
  • Higher risk in patients with hepatic impairment
  • Not recommended for patients with neutrophil counts <1500 cells/mm3
  • Fatal cases of enterocolitis reported
  • Severe hypersensitivity reactions may occur
  • Treatment related acute myeloid leukemia may occur

Overdose Effects

No known antidote, close monitoring of vital functions, anticipated complications of bone marrow suppression, peripheral neurotoxicity, and mucositis

Therapeutic Class

Cytotoxic Chemotherapy

Storage Conditions

Store between 2°C and 25°C, protected from light, freezing does not adversely affect the product

Related Brands