Docetaxel Axios 80 mg/vial (IV Infusion)
Medicine Details
| Category | Details |
|---|---|
| Generic | Docetaxel trihydrate |
| Company | Bots pvt limited |
| Also available as |
Title
Docetaxel Axios
Categories
- Chemotherapy
- Antineoplastic Agent
- Cytotoxic Chemotherapy
Description
Docetaxel Axios is a microtubule inhibitor indicated for various cancers such as Breast Cancer, Non-small Cell Lung Cancer, Prostate Cancer, Gastric Adenocarcinoma, and Squamous Cell Carcinoma of the Head and Neck.
Indications
- Breast Cancer treatment
- Non-small Cell Lung Cancer treatment
- Prostate Cancer treatment
- Gastric Adenocarcinoma treatment
- Squamous Cell Carcinoma of the Head and Neck treatment
Mode of Action
Disrupts microtubular network, vital for cellular functions, promotes tubulin assembly, inhibits disassembly, binds to free tubulin, decreases intracellular tubulin concentration
Dosage & Administration
- Administer intravenously
- Premedicate with oral corticosteroids
- Adjust dose as needed
Interaction
CYP3A4 substrate, metabolism may be modified by concomitant administration of compounds
Contraindications
- Neutrophil counts <1500 cells/mm3
- History of severe hypersensitivity reactions to docetaxel or other drugs formulated with polysorbate 80
Side Effects
- Infections
- Neutropenia
- Anemia
- Febrile neutropenia
- Hypersensitivity
- Thrombocytopenia
- Neuropathy
- Dysgeusia
- Dyspnea
- Constipation
- Anorexia
- Nail disorders
- Fluid retention
- Asthenia
- Pain
- Nausea
- Diarrhea
- Vomiting
- Mucositis
- Alopecia
- Skin reactions
- Myalgia
Pregnancy & Lactation
Can cause fetal harm when administered to a pregnant woman, no information on effects on milk production or breastfed child
Precautions & Warnings
- Use under supervision of experienced physician
- Higher risk in patients with hepatic impairment
- Not recommended for patients with neutrophil counts <1500 cells/mm3
- Fatal cases of enterocolitis reported
- Severe hypersensitivity reactions may occur
- Treatment related acute myeloid leukemia may occur
Overdose Effects
No known antidote, close monitoring of vital functions, anticipated complications of bone marrow suppression, peripheral neurotoxicity, and mucositis
Therapeutic Class
Cytotoxic Chemotherapy
Storage Conditions
Store between 2°C and 25°C, protected from light, freezing does not adversely affect the product