Docetaxel HEXAL 80 mg/vial (IV Infusion)

80 mg vial: ৳ 12,140.00

Medicine Details

Category	Details
Generic	Docetaxel trihydrate
Company	Sandoz a novartis division
Also available as	Docetaxel hexal 20 mg injection

Indications

Breast Cancer (BC): single agent for locally advanced or metastatic BC after chemotherapy failure
Breast Cancer (BC): with doxorubicin and cyclophosphamide as adjuvant treatment of operable node-positive BC
Non-small Cell Lung Cancer (NSCLC): single agent for locally advanced or metastatic NSCLC after platinum therapy failure
Castration-Resistant Prostate Cancer (CRPC): with prednisone in metastatic castration-resistant prostate cancer
Gastric Adenocarcinoma (GC): with cisplatin and fluorouracil for untreated, advanced GC
Squamous Cell Carcinoma of the Head and Neck (SCCHN): with cisplatin and fluorouracil for induction treatment of locally advanced SCCHN

Pharmacology

Acts by disrupting the microtubular network in cells essential for vital mitotic and interphase cellular functions. Promotes assembly of tubulin into stable microtubules while inhibiting their disassembly.

Dosage & Administration

Administered intravenously (IV) over 1 hr every 3 weeks
Dosage varies for different indications such as BC, NSCLC, HRPC, GC, and SCCHN
Premedication with oral corticosteroids is recommended
Adjust dose as needed

Interaction

It is a CYP3A4 substrate, and its metabolism may be modified by the concomitant administration of certain compounds.

Contraindications

Neutrophil counts of <1500 cells/mm3
A history of severe hypersensitivity reactions to docetaxel or to other drugs formulated with polysorbate 80

Side Effects

Infections
Neutropenia
Anemia
Febrile neutropenia
Hypersensitivity
Thrombocytopenia
Neuropathy
Dysgeusia
Dyspnea
Constipation
Anorexia
Nail disorders
Fluid retention
Asthenia
Pain
Nausea
Diarrhea
Vomiting
Mucositis
Alopecia
Skin reactions
Myalgia

Pregnancy & Lactation

Can cause fetal harm when administered to a pregnant woman. No information on presence in human milk or effects on milk production or the breastfed child.

Precautions & Warnings

Should be administered under the supervision of a physician experienced in the use of antineoplastic agents
Higher risk of severe adverse reactions in patients with hepatic impairment
Should not be given to patients with neutrophil counts of less than 1,500 cells/mm3
Severe hypersensitivity reactions may occur, requiring immediate discontinuation
Treatment related acute myeloid leukemia may occur

Overdose Effects

No known antidote for docetaxel overdose. Expected complications include bone marrow suppression, peripheral neurotoxicity, and mucositis.

Therapeutic Class

Cytotoxic Chemotherapy

Storage Conditions

Store between 2°C and 25°C and protected from light. Freezing does not adversely affect the product.