Fludarabin Hexal 50 mg/2 ml (IV Infusion)
50 mg vial: ৳ 6,614.00
Medicine Details
Category | Details |
---|---|
Generic | Fludarabine phosphate |
Company | Sandoz a novartis division |
Indications
- Treatment of B-cell chronic lymphocytic leukemia (CLL)
- Non-responsive or progressive CLL treatment
Pharmacology
- Metabolized to 2-fluoro-ara-A
- Phosphorylated intracellularly by deoxycytidine kinase
- Inhibition of DNA polymerase alpha
- Inhibition of ribonucleotide reductase
- Inhibition of DNA primase
- Inhibition of DNA synthesis leading to cell death
Dosage & Administration
- Recommended dosage for intravenous administration
- Dosage calculation based on body surface area
- Instructions for preparation and administration of intravenous bolus injection
- Instructions for preparation and administration of intravenous infusion
- Recommended dosage for oral administration
Interaction
- Contraindication of combination with pentostatin
- Potential reduction of therapeutic efficacy when combined with dipyridamole
- Increased intracellular concentration of Ara-CTP when combined with cytarabine
Contraindications
- Hypersensitivity to the active substance or excipients
- Renal impairment with creatinine clearance <30 ml/min
- Decompensated hemolytic anemia
Side Effects
- Bone marrow suppression
- Central nervous system problems
- Low red blood cell count
- Lung toxicity when used in specific combination
Pregnancy & Lactation
- Limited data on use during the first trimester
- Reported pregnancy loss and premature delivery
- Discontinuation of breastfeeding during treatment
Precautions & Warnings
- Administration under supervision of qualified physician
- Association with myelosuppression
- Association with irreversible CNS effects
- Association with auto-immune hemolytic anemia
- Contradiction with specific combination therapy
Use in Special Populations
- Dosage adjustment for renal impairment
Therapeutic Class
- Cytotoxic chemotherapy
Storage Conditions
- Injection storage below 25°C
- In-use storage times and conditions
- Tablet storage between 15°C and 30°C
- Protection from freezing
- Storage out of reach and sight of children