Fludarabin Hexal 50 mg/2 ml (IV Infusion)

50 mg vial: ৳ 6,614.00

Medicine Details

Indications

  • Treatment of B-cell chronic lymphocytic leukemia (CLL)
  • Non-responsive or progressive CLL treatment

Pharmacology

  • Metabolized to 2-fluoro-ara-A
  • Phosphorylated intracellularly by deoxycytidine kinase
  • Inhibition of DNA polymerase alpha
  • Inhibition of ribonucleotide reductase
  • Inhibition of DNA primase
  • Inhibition of DNA synthesis leading to cell death

Dosage & Administration

  • Recommended dosage for intravenous administration
  • Dosage calculation based on body surface area
  • Instructions for preparation and administration of intravenous bolus injection
  • Instructions for preparation and administration of intravenous infusion
  • Recommended dosage for oral administration

Interaction

  • Contraindication of combination with pentostatin
  • Potential reduction of therapeutic efficacy when combined with dipyridamole
  • Increased intracellular concentration of Ara-CTP when combined with cytarabine

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Renal impairment with creatinine clearance <30 ml/min
  • Decompensated hemolytic anemia

Side Effects

  • Bone marrow suppression
  • Central nervous system problems
  • Low red blood cell count
  • Lung toxicity when used in specific combination

Pregnancy & Lactation

  • Limited data on use during the first trimester
  • Reported pregnancy loss and premature delivery
  • Discontinuation of breastfeeding during treatment

Precautions & Warnings

  • Administration under supervision of qualified physician
  • Association with myelosuppression
  • Association with irreversible CNS effects
  • Association with auto-immune hemolytic anemia
  • Contradiction with specific combination therapy

Use in Special Populations

  • Dosage adjustment for renal impairment

Therapeutic Class

  • Cytotoxic chemotherapy

Storage Conditions

  • Injection storage below 25°C
  • In-use storage times and conditions
  • Tablet storage between 15°C and 30°C
  • Protection from freezing
  • Storage out of reach and sight of children

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