Gemzar 1 gm/vial (IV Infusion)

1 gm vial: ৳ 10,916.00

Medicine Details

Category Details
Generic Gemcitabine
Company Eli lilly and company
Also available as
Gemzar 200 mg injection Gembine 200 mg injection Gembine 1 gm injection

Indications

  • Non-Small Cell Lung Cancer treatment
  • First-line treatment of locally advanced or metastatic non-small cell lung cancer
  • Palliative treatment of adult patients with non-small cell lung cancer
  • Treatment of locally advanced or metastatic adenocarcinoma of the pancreas
  • Treatment of 5-FU refractory pancreatic cancer
  • Treatment of advanced bladder cancer in combination with Cisplatin therapy
  • Treatment of metastatic breast cancer in patients who have relapsed following adjuvant/neoadjuvant chemotherapy
  • Treatment of recurrent epithelial ovarian carcinoma in patients who have relapsed following platinum-based therapy

Pharmacology

  • Metabolism by nucleoside kinases
  • Cytotoxic action: inhibition of DNA synthesis
  • Inhibition of ribonucleotide reductase
  • Competition with dCTP for incorporation into DNA
  • Induction of the programmed cellular death process known as apoptosis

Dosage & Administration

  • Recommended dosage for Non-Small Cell Lung Cancer
  • Recommended dosage for Pancreatic Cancer
  • Recommended dosage for Bladder Cancer
  • Recommended dosage for Breast Cancer
  • Recommended dosage for Ovarian Cancer
  • Dosing regimens for combination use
  • Dose reduction based on toxicity experienced by the patient

Interaction

  • No confirmed interactions reported
  • No specific drug interaction studies conducted

Contraindications

  • Contraindicated in patients with known hypersensitivity to Gemcitabine

Side Effects

  • Haematological Toxicity
  • Hepatic Toxicity
  • Gastrointestinal toxicity
  • Genito-Urinary Toxicity
  • Pulmonary Toxicity
  • Allergic Toxicity
  • Neurotoxicity
  • Alopecia

Pregnancy & Lactation

  • Pregnancy Category D
  • Use during pregnancy
  • Unknown excretion in human breast milk

Precautions & Warnings

  • Risk of Schedule-dependent Toxicity
  • Myelosuppression
  • Pulmonary Toxicity and Respiratory Failure
  • Hemolytic Uremic Syndrome
  • Hepatic Toxicity
  • Embryofetal Toxicity
  • Radiation Therapy Toxicity
  • Impairment of Fertility

Use in Special Populations

  • Elderly Patients
  • Renal and Hepatic Impairment
  • Use in Children

Overdose Effects

  • No known antidote for overdoses
  • Myelosuppression
  • Paresthesias
  • Severe rash

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store at 20-25°C away from light
  • Do not refrigerate as crystallisation may occur
  • Keep out of the reach of children

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