Traxyl 500 mg/5 ml (IM/IV Injection)
5 ml ampoule: ৳ 60.00 (2 x 5: ৳ 600.00)
Medicine Details
Category | Details |
---|---|
Generic | Tranexamic acid |
Company | Nuvista pharma ltd |
Also available as |
Indications
- Prophylaxis and therapy of hemophtoes
- Digestive hemorrhages
- Hemorrhagic syndromes in leukaemia
- Cirrhosis and Hemophilia
- Thrombocytopenic purpura
- Accidents during thrombolytic therapy and transfusion
- Prophylaxis and antihemorrhagic therapy during operations of any type
- Prophylaxis and antihemorrhagic therapy of prostatic, vesical and renal surgery
- Prophylaxis and therapy of post-partum and puerperium hemorrhages
- Prophylaxis and antihemorrhagic therapy during a tonsillectomy
- Prophylaxis and antihemorrhagic therapy during maxillofacial operations
- To promote the formation of a fibrin capsule to wall off and inhibit the growth of ovarian tumors
- To cause regression of ascites secondary to carcinoma
- To reduce bleeding during surgical interventions
Pharmacology
- Preparation of tranexamic acid (trans-4 aminomethyl-cyclohexanecarboxylic acid)
- Strong antifibrinolytic action
- Inhibition of plasminogen activation
- Low acute and chronic toxicity
- Well absorbed by oral route
- Excreted mainly by renal route
- No interference with clotting processes
Dosage & Administration
- Usual dose for adults: 500-1000 mg 3 times daily
- Recommended daily doses for prophylaxis: 0.5-1 gm orally, 500 mg by the parenteral route
- Increased oral dose for therapy of hemorrhagic manifestations: 1-3 gm
- Dosage for children based on body weight
Interaction
- Incompatible with solutions containing penicillins
- Antagonized by thrombolytic drugs like Streptokinase & Urokinase
- Potential for increased thrombus formation with concomitant administration of estrogen-containing drugs
Contraindications
- Known individual hypersensitivity
- Thromboembolic disease
- Arterial and venous thrombosis
- Endocavitary hemorrhages
- Serious kidney failure
Side Effects
- Sense of fatigue
- Conjunctival irritation
- Nasal blockage
- Itching
- Skin reddening
- Exanthems
- Nausea
- Diarrhea
- Gastric pyrosis
- Postural hypotension
- Hypersensitivity reactions
Pregnancy & Lactation
- Should not be administered during known and presumed pregnancy
- Passes into breast milk to a low concentration unlikely to cause antifibrinolytic effect in the infant
Precautions & Warnings
- Use in cases of hyperfibrinolysis
- Prophylactic treatment timing
- Prolonged therapy after hemorrhage disappearance
- Dose adjustment in hematuria
- Caution in renal insufficiency, cardiopathic, and hepatopathic subjects
Therapeutic Class
- Anti-fibrinolytic drugs
- Haemostatic drugs
Storage Conditions
- Store in a dry place at 15-30°C
- Away from light
- Keep out of children's reach
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