MM Kit 200 mg+200 mcg (Tablet)
(1+4) tablet kit: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Mifepristone misoprostol |
| Company | Ziska pharmaceuticals ltd |
Indications
- Early Menstrual Regulation (MR)
- Termination of pregnancy up to 9 weeks of gestation
Composition
- Each box contains 2 blister strips
- One strip contains 1 tablet of Mifepristone INN 200 mg
- Another strip contains 4 tablets of Misoprostol USP 200 microgram each
Pharmacology
- Mifepristone is a synthetic steroid with anti-progestational activity
- Mifepristone inhibits the activity of endogenous or exogenous progesterone
- Mifepristone sensitizes the myometrium to the contraction-inducing activity of prostaglandins
- Misoprostol is a synthetic analogue of prostaglandin E1
- Misoprostol causes myometrial contraction by interacting with specific receptors
- Misoprostol causes the cervix to soften and the uterus to contract
Dosage & Administration
- Mifepristone administration: One tablet of Mifepristone (200 mg) is taken in a single oral dose
- Misoprostol administration: 800 micrograms of Misoprostol is taken buccally or sublingually 24-48 hours after Mifepristone
- Post-treatment examination is required within 10 to 14 days after Mifepristone administration
Interaction
- Mifepristone metabolism may be inhibited by Ketoconazole, Itraconazole, Erythromycin, and grapefruit juice
- Misoprostol does not interfere with the beneficial effects of aspirin
Contraindications
- Known allergy or hypersensitivity to Mifepristone, Misoprostol, or other prostaglandins
- Confirmed or suspected ectopic pregnancy
- Chronic adrenal failure
- Haemorrhagic disorders or concurrent anticoagulant therapy
- Inherited porphyria
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Pelvic pain
- Fainting
- Headache
- Dizziness
- Asthenia
- Abdominal pain
- Flatulence
- Dyspepsia
- Shivering
- Hyperthermia
- Severe vaginal bleeding
- Shock
- Uterine rupture
Pregnancy & Lactation
- Mifepristone is indicated for Menstrual Regulation (MR) and has no other approved indication for use during pregnancy
- Mifepristone effects on infants through breast milk is unknown
- Misoprostol should not be administered to nursing mothers
Precautions & Warnings
- Combination of Mifepristone & Misoprostol should not be given to anyone else
- Intra Uterine Device (IUD) should be removed before treatment with Mifepristone
- Surgical termination is recommended in cases of treatment failure
- Patients with hepatic disease should receive a decreased dose of Misoprostol
Use in Special Populations
- Patients with hepatic impairment should receive a decreased dose of Misoprostol
- No routine dosage adjustment is recommended in older patients or patients with renal impairment for Misoprostol
Overdose Effects
- No serious adverse reactions reported in tolerance studies for Mifepristone
- Clinical signs of Misoprostol overdose are sedation, tremor, convulsions, dyspnea, abdominal pain, diarrhoea, fever, palpitations, hypotension, or bradycardia
Therapeutic Class
- Drugs acting on the Uterus
- Prostaglandin analogues
Storage Conditions
- Store in a cool and dry place
- Protected from light