Flucoder 200 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluconazole |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Vaginal Candidiasis
- Oropharyngeal Candidiasis
- Oesophageal Candidiasis
- Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea
- Kerion
- Pityriasis versicolor
- Onychomycosis
- Invasive candidal infections and cryptococcal infections (including meningitis)
- Prevention of cryptococcal meningitis
- Prevention of fungal infections in immunocompromised patients
- Systemic Candidiasis and Cryptococcal infection
- Superficial Candidiasis
- Fungal urinary tract infections
- Disseminated candidiasis
- Prophylaxis for fungal infection in neutropenic cancer patients
- Acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis
Pharmacology
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes and responsible for the synthesis of ergosterol.
Dosage & Administration
- Dosage varies for different indications such as Vaginal Candidiasis, Oropharyngeal Candidiasis, Oesophageal Candidiasis, Tinea corporis/Tinea cruris/Tinea pedis/Other Tinea, Kerion, Pityriasis versicolor, Onychomycosis, and more
- Specific dosages for children based on weight
- Dosage modifications for elderly patients and those with renal impairment
Interaction
Fluconazole interacts with drugs like warfarin, sulphonyl ureas, hydrochlorothiazide, phenytoin, rifampicin, combined oral contraceptive, cyclosporin, theophyline, and more
Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds
Side Effects
Common side effects include symptoms associated with the gastrointestinal tract, nausea, abdominal discomfort, diarrhea, and flatulence. Other adverse events such as rash are rarely encountered (Incidence less than 1%). Anaphylaxis has been reported in rare cases.
Pregnancy & Lactation
Fluconazole adverse fetal effects have been seen in animals only at dose levels associated with maternal toxicity. Its use in pregnancy or in women of child bearing potential is not recommended unless adequate contraception is employed.
Precautions & Warnings
- Abnormalities of hepatic, renal, haematological and other biochemical function tests have been observed in some patients
- Patients have rarely developed exfoliative cutaneous reactions, such as Stevens Johnson Syndrome and toxic epidermal necrolysis, during treatment with Fluconazole
- Use during lactation is not recommended
- Experience with Fluconazole indicates that therapy is unlikely to impair a patient's ability to drive or use machinery
Use in Special Populations
- Use in the elderly
- Use in renal impairment with dosage adjustments based on creatinine clearance
Overdose Effects
In the event of overdosage, supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate. Forced volume diuresis would probably increase the elimination rate. Haemodialysis decreases plasma levels by approximately 50%
Therapeutic Class
Drugs for subcutaneous and mycoses
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children