R-Pil 5 mg (Tablet)

Unit Price: ৳ 8.03 (3 x 10: ৳ 240.92)
Strip Price: ৳ 80.31

Medicine Details

Category Details
Generic Ramipril
Company Biopharma limited
Also available as
R pil 125 mg tablet R pil 25 mg tablet

Title

  • R-Pil Tablet

Category

  • Medicine
  • Healthcare
  • Pharmaceutical

Description

  • R-Pil is indicated for the management of hypertension
  • It is also used in the treatment of congestive heart failure
  • It is prescribed for patients with acute myocardial infarction
  • It reduces the risk of myocardial infarction, stroke, or cardiovascular death
  • It is used for the treatment of non-diabetic or diabetic overt glomerular or incipient nephropathy

Dosage

  • Initial dose for hypertension: 1.25-2.5 mg once daily
  • Maintenance dosage for hypertension: 2.5-20 mg daily
  • Initial dose for congestive heart failure after myocardial infarction: 2.5 mg twice daily
  • Target daily dose for congestive heart failure after myocardial infarction: 5 mg twice daily
  • Recommended dose for prevention of major cardiovascular events: 2.5 mg once daily for the first week, then 5 mg once daily for the following 3 weeks

Administration

  • Tablet form to be swallowed with sufficient liquid
  • Absorption not significantly affected by food

Interaction

  • Concomitant administration with diuretics may lead to serious hypotension
  • Concomitant therapy with lithium may increase the serum lithium concentration
  • NSAIDs may reduce the antihypertensive effect
  • Reduction in BP may affect the ability to drive and operate machinery

Contraindications

  • Hypersensitivity to ramipril or any other ACE inhibitor
  • History of angioedema
  • Concomitant use with sacubitril/valsartan therapy
  • Haemodynamically relevant renal artery stenosis
  • Hypotensive or haemodynamically unstable states
  • Concomitant use with aliskiren-containing medicines in patients with diabetes or with moderate to severe renal impairment
  • Concomitant use with angiotensin II receptor antagonists (AIIRAs) in patients with diabetic nephropathy
  • During pregnancy and breastfeeding

Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Asthenia
  • Symptomatic hypotension
  • Cough
  • Nausea
  • Vomiting
  • Diarrhoea
  • Rash
  • Urticaria
  • Oliguria
  • Anxiety
  • Amnesia
  • Angioneurotic oedema
  • Anaphylactic reactions
  • Hyperkalaemia

Pregnancy & Lactation

  • Must not be taken during pregnancy
  • Pregnancy must be excluded before starting treatment
  • Pregnancy must be avoided in cases where treatment with ACE inhibitors is indispensable
  • Not recommended during breastfeeding

Precautions & Warnings

  • Use with caution in patients with impaired renal function
  • Use with caution in patients with hyperkalaemia
  • Use with caution in patients with hypotension
  • Use with caution in patients with impaired hepatic function

Use in Special Populations

  • Elderly: Reduced initial dose must be considered
  • Hepatic impairment: Treatment must be initiated under close medical supervision
  • Renal impairment: Initial daily dose varies based on creatinine clearance
  • Patients pretreated with a diuretic: Consideration must be given to discontinuing the diuretic

Overdose Effects

  • Excessive peripheral vasodilatation
  • Marked hypotension
  • Shock
  • Bradycardia
  • Electrolyte disturbances
  • Renal failure

Therapeutic Class

  • Angiotensin-converting enzyme (ACE) inhibitors

Storage Conditions

  • Store at 30°C or below
  • Protect from light
  • Keep out of the reach of children

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