Tritace 2.5 mg (Tablet)
Unit Price: ৳ 9.53 (2 x 14: ৳ 266.84)
Strip Price: ৳ 133.42
Medicine Details
| Category | Details |
|---|---|
| Generic | Ramipril |
| Company | Synovia pharma plc |
| Also available as |
Indications
- Lowering blood pressure
- Management of hypertension
- Treatment of congestive heart failure
- Treatment after acute myocardial infarction
- Treatment of glomerular or incipient nephropathy
- Reduction of cardiovascular risk
Pharmacology
- Angiotensin converting enzyme (ACE) inhibitor
- Blocks conversion of angiotensin I to angiotensin II
- Decreases vasopressor activity
- Decreases aldosterone secretion
- Long-acting and well-tolerated
Dosage
- Adjusted according to patient tolerance and response
- Initial dose for hypertension: 1.25-2.5 mg once daily
- Maintenance dosage for hypertension: 2.5-20 mg daily
- Dosage for congestive heart failure after myocardial infarction: 2.5 mg twice daily
- Recommended dosage for prevention of major cardiovascular events
- Dosage adjustments for renal impairment
Administration
- Tablets must be swallowed whole
- Absorption not significantly affected by food
- Can be taken before, during, or after a meal
Interaction
- Concomitant administration with diuretics may lead to hypotension
- Concomitant therapy with lithium may increase serum lithium concentration
- Reduction in BP may affect ability to drive
- NSAIDs may reduce antihypertensive effect
- Caution with alcohol consumption
Contraindications
- Hypersensitivity to ramipril or any other ACE inhibitor
- History of angioedema
- Concomitant use with sacubitril/valsartan therapy
- Renal artery stenosis
- Hypotensive or haemodynamically unstable states
- Concomitant use of aliskiren-containing medicines
- Concomitant use with angiotensin II receptor antagonists (AIIRAs)
- During pregnancy and breastfeeding
- Concomitant use with extracorporeal treatments
Side Effects
- Dizziness
- Headache
- Fatigue
- Symptomatic hypotension
- Cough
- Nausea
- Vomiting
- Diarrhoea
- Rash
- Urticaria
- Oliguria
- Anxiety
- Amnesia
- Angioneurotic oedema
- Anaphylactic reactions
- Hyperkalaemia
Pregnancy & Lactation
- Not to be taken during pregnancy
- Pregnancy must be excluded before starting treatment
- Pregnancy must be avoided when treatment is indispensable
- Discontinue ACE inhibitors if patient intends to become pregnant
- Not recommended during breastfeeding
Precautions & Warnings
- Use with caution in patients with impaired renal function
- Use with caution in patients with hyperkalaemia
- Use with caution in patients with hypotension
- Use with caution in patients with impaired hepatic function
Use in Special Populations
- Reduced initial dose for elderly patients
- Close medical supervision for patients with hepatic impairment
- Considerations for dosage in patients with renal impairment
Overdose Effects
- Excessive peripheral vasodilatation
- Marked hypotension
- Bradycardia
- Electrolyte disturbances
- Renal failure
- Management: gastric lavage, administration of adsorbents, sodium sulfate, alpha1-adrenergic agonists
Therapeutic Class
- Angiotensin-converting enzyme (ACE) inhibitors
Storage Conditions
- Store at 30°C or below
- Protect from light
- Keep out of the reach of children
- Do not use later than the date of expiry
- To be dispensed only on the prescription of a registered physician