Leveron 500 mg/5 ml (Oral Solution)
100 ml bottle: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levetiracetam |
| Company | Synovia pharma plc |
| Also available as |
Indications
- Treatment of partial-onset seizures in adults and adolescents
- Adjunctive therapy for partial-onset seizures in adults, adolescents, children, and infants
- Treatment of myoclonic seizures in adults and adolescents
- Treatment of primary generalized tonic-clonic seizures in adults and adolescents
Description
- Mechanism of antiepileptic effect unknown
- Activity in submaximal stimulation and threshold tests
- Protection against secondarily generalized activity
- Inhibition of burst firing
- Prevention of hyper synchronization
Dosage
- Recommended starting dose for adults and adolescents
- Initial therapeutic dose for adults and adolescents weighing 50 kg or more
- Use of oral solution for pediatric population
- Monotherapy use in adults and adolescents
- Add-on therapy use in children and infants
Administration
- Oral administration
- Swallowed with sufficient quantity of liquid
- Taken with or without food
- Daily dose administered in two equally divided doses
Interaction
- No influence on serum concentrations of existing antiepileptic drugs
- Inhibition of renal clearance of primary metabolite by Probenecid
- Impact on methotrexate clearance
- Reports of decreased efficacy with osmotic laxative
- Absorption not altered by food, but rate slightly reduced
Contraindications
- Hypersensitivity to active substance or other pyrrolidone derivatives
Side Effects
- Most common adverse reactions in adult patients
- Most common adverse reactions in pediatric patients
Pregnancy & Lactation
- Not recommended during pregnancy
- Excreted in human breast milk
- Breastfeeding not recommended
- No impact on fertility in animal studies
Precautions & Warnings
- Dose adjustment for renal impairment
- Association with acute kidney injury
- Rare cases of decreased blood cell counts
- Risk of suicide, suicidal ideation, and behavior
- Impact on pediatric population
Use in Special Populations
- Dose adjustment in elderly with compromised renal function
- Individualized dose according to renal function
- No dose adjustment in mild to moderate hepatic impairment
- Recommended dose reduction in severe hepatic impairment
Overdose Effects
- Observation of somnolence, agitation, aggression
- Depressed level of consciousness, respiratory depression, and coma
- No specific antidote
- Symptomatic treatment
- Possible inclusion of haemodialysis
Therapeutic Class
- Adjunct anti-epileptic drugs
Storage Conditions
- Store at a cool temperature not exceeding 25°C
- Dry place, protected from light