Metsa XR 1000 mg (Tablet (Extended Release))
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Synovia pharma plc |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in adults
- Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight type 2 diabetic adult patients
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Usual starting dose of 500 mg twice a day for adults
- Usual starting dose of 500 mg twice a day for children
- Recommended dosage increases for adults and children
- Maximum recommended daily doses for adults and children
- Instructions for Metformin extended release tablet
Interaction
- No information available about the chronic co-administration with Furosemide
- Nifedipine appears to enhance the absorption of Metsa XR
- Potential interaction with cationic drugs and renal tubular transport systems
- Minimal effects on Cimetidine pharmacokinetics
- Drugs that tend to produce hyperglycemia and may lead to loss of glycemic control
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions with potential to alter renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Uncontrolled diabetes during pregnancy associated with increased risk of congenital abnormalities and perinatal mortality
- Recommendation to use insulin instead of metformin during pregnancy
- Excretion of Metformin into human breast milk
- No adverse effects observed in breastfed newborns/infants
Precautions & Warnings
- Substantial excretion by the kidney
- Decrease in vitamin B12 level
- Increased risk of hypoglycemia when used in combination with insulin
- Regular monitoring of renal function
- Cautious use in conditions causing dehydration, serious infections, or trauma
- Annual estimation of Vitamin B-12 levels
- Cautious use with sulphonylurea and concomitant therapy with insulin
- Interaction with cimetidine and anticoagulants
Use in Special Populations
- Adjustment of metformin dosage based on renal function in elderly subjects
- Regular assessment of renal function in elderly
- Recommendation for careful follow-up of effect on growth and puberty in metformin-treated children
- Particular caution recommended in prescribing to children aged between 10 and 12 years
- Creatinine clearance determination before initiating treatment
- Regular GFR assessment before and during treatment
Overdose Effects
- Hypoglycemia not seen at doses up to 85 gm
- Lactic acidosis occurred in such circumstances
- Treatment involves hospital care
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children