Qpine 200 mg (Tablet)

Unit Price: ৳ 18.05 (3 x 10: ৳ 541.50)
Strip Price: ৳ 180.50

Medicine Details

Category Details
Generic Quetiapine fumarate
Company Synovia pharma plc
Also available as
Qpine 25 mg tablet Qpine 100 mg tablet

Indications

  • Treatment of Acute and chronic psychoses
  • Treatment of schizophrenia
  • Treatment of Bipolar Disorder
  • Maintenance treatment of bipolar I disorder
  • Prevention of recurrence of manic, depressive or mixed episodes

Pharmacology

  • Belongs to dibenzothiazepine derivatives
  • Antagonist at multiple neurotransmitter receptors in the brain
  • No appreciable affinity at cholinergic muscarinic and benzodiazepine receptors
  • Mechanism of action is unknown
  • Efficacy in schizophrenia is mediated through a combination of dopamine D2 and serotonin 5HT2 antagonism

Dosage & Administration

  • Administered twice daily
  • Can be administered with or without food
  • Dosage titrated based on clinical response and tolerability
  • Recommended dosage range for different conditions

Interaction

  • Caution with medicines causing electrolyte imbalance or increasing QT interval
  • Increased clearance when used concomitantly with thioridazine, carbamazepine, and phenytoin

Contraindications

  • Contra-indicated in patients who are hypersensitive to it

Side Effects

  • Somnolence
  • Dizziness
  • Dry mouth
  • Elevations in serum triglyceride levels
  • Weight gain
  • Decreased haemoglobin
  • Extrapyramidal symptoms

Pregnancy & Lactation

  • Safety and efficacy during human pregnancy not established
  • Use during pregnancy only if benefits justify the potential risks
  • Avoid breastfeeding while taking it

Precautions & Warnings

  • Risk of suicidal thoughts and self-harm
  • Caution in patients with known cardiovascular or cerebrovascular disease
  • Caution in patients with a history of seizures
  • Consideration of dose reduction or discontinuation if signs of tardive dyskinesia appear
  • Caution in patients with a family history of QT prolongation
  • Possible occurrence of neutropenia, hyperglycemia, and diabetes mellitus

Use in Special Populations

  • Caution in the elderly
  • Not indicated for use in children and adolescents below 18 years of age

Overdose Effects

  • Survival reported in acute overdoses of up to 30 grams
  • No specific antidote
  • Intensive care procedures recommended
  • Close medical supervision and monitoring required

Therapeutic Class

  • Atypical neuroleptic drugs

Storage Conditions

  • Keep out of the sight and reach of children
  • Do not use after the expiry date
  • Store in a cool, dry place away from light

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