Sergel 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Esomeprazole
Company Healthcare pharmaceuticals ltd
Also available as
Sergel 20 mg capsule Sergel 40 mg capsule Sergel 40 mg injection Sergel 20 mg tablet Sergel 20 mg powder

Title

Sergel 40 mg Tablet

Categories

  • Medicine
  • Health
  • Pharmacology

Description

Sergel 40 mg Tablet is a proton pump inhibitor used to relieve chronic heartburn symptoms, heal erosive esophagitis, eradicate Helicobacter pylori infection, and treat Zollinger-Ellison Syndrome, acid-related dyspepsia, and duodenal & gastric ulcers. It works by suppressing gastric acid secretion and is available in oral and IV forms.

Attributes

  • Indications:
    • Relief from chronic heartburn symptoms
    • Healing of erosive esophagitis
    • Maintenance of healing of erosive esophagitis
    • Eradication of Helicobacter pylori infection
    • Treatment of Zollinger-Ellison Syndrome
    • Management of acid-related dyspepsia
    • Duodenal & gastric ulcer
  • Mode of Action:
    • Proton pump inhibitor
    • Specific inhibition of H+/K+-ATPase
    • Better acid control with single optical isomer
    • Absorption in 1.5 hours after oral administration
    • Metabolized in the liver by cytochrome P450 enzyme system
  • Dosage:
    • 20 mg or 40 mg Once Daily for healing of erosive esophagitis
    • 20 mg Once Daily for maintenance of healing of erosive esophagitis
    • 20 mg Once Daily for symptomatic GERD for 4 weeks
    • 40 mg Once Daily for Helicobacter pylori eradication
    • 20-80 mg Once Daily for Zollinger-Ellison Syndrome
    • 20-40 mg Once Daily for acid-related dyspepsia for 2-4 weeks
    • 20 mg Once Daily for 2-4 weeks for duodenal ulcer
    • 20-40 mg Once Daily for 4-8 weeks for gastric ulcer
    • IV Injection: 20 mg or 40 mg once daily for adults
  • Administration:
    • Tablet or capsule: Swallow whole one hour before a meal
    • Oral Suspension: Mix with water and drink within 30 minutes
    • IV Injection: Administer intravenously over at least 3 minutes
  • Interaction:
    • Extensively metabolized by CYP2C19 and CYP3A4
    • Inhibition of CYP2C19 by Sergel
    • Possible interference with absorption of drugs influenced by gastric pH
  • Contraindications:
    • Known hypersensitivity to any of the formulation
  • Side Effects:
    • Headache
    • Diarrhoea
    • Nausea
    • Flatulence
    • Abdominal pain
    • Constipation
    • Dry mouth
  • Pregnancy & Lactation:
    • No adequate and well-controlled studies in pregnant women
    • No study on excretion in milk
    • Breastfeeding should be discontinued if essential
  • Precautions & Warnings:
    • Symptomatic response does not exclude gastric malignancy
    • Take capsules one hour before meals
    • Use applesauce for patients who struggle with capsule swallowing
    • Use of antacids while taking Sergel
  • Use in Special Populations:
    • Safety and efficacy not established in pediatric patients
    • No overall differences in the elderly
    • No dosage adjustment for mild to moderate hepatic insufficiency
    • No alteration in renal impairment
  • Overdose Effects:
    • Acute toxicity in rats with lethal dose
    • Reduced motor activity
    • Changes in respiratory frequency
    • Tremor and ataxia
    • No specific antidote known
  • Storage Conditions:
    • Store at temperature not exceeding 30°C
    • Protect from light and moisture
    • Keep out of reach of children
  • Chemical Structure:
    • Molecular Formula: C17H19N3O3S
  • Common Questions:
    • Uses of Sergel 40 mg Tablet
    • Side effects of Sergel 40 mg Tablet
    • Use during pregnancy or breastfeeding
    • Time taken for Sergel 40 mg Tablet to work
    • Quick Tips for using Sergel 40 mg Tablet

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